Cast[]
- Duke as Theodore
- Max as Hank
- Chloe as Emily
- Dr. Nefario (from Despicable Me) as George
- Snowball as Foduck
- Max and Duke's Owner as Rebecca
- Silas Ramsbottom (from Despicable Me 2) as Beddeck
- Sean (from Journey 2: The Mysterious Island) as Northumberland Submarine
- The Once-ler's Mom (from Dr. Seuss' The Lorax) as Carla
- Kailani (from Journey 2: The Mysterious Island) as Pugwash
- Mel as Oliver
- Grammy Norma (from Dr. Seuss' The Lorax) as Sigrid
- Hank (from Journey 2: The Mysterious Island) as Fundy
- Vector (from Despicable Me) as Cabot
- Anges (from Despicable Me) as Bluenose