Cast[]
- Max as Alvin
- Reginald as Simon
- E.B. (from Hop) as Theodore
- Gidget as Brittany
- Chloe as Jeanette
- Fluffy (from Hop) as Eleanor
- Gru (from Despicable Me 2) as Dave Seville
- Grammy Norma (from Dr. Seuss' The Lorax) as Miss Miller
- Marilyn's Cat as Vinny
- Snowball as Uncle Harry
- Dr. Nefario (from Despicable Me) as Uncle Willy
- Marilyn as Miss Stone/Dr. Rubin
- Vector (from Despicable Me) as Ian Hawke
- Lucy (from Despicable Me 2) as Claire Wilson
- Mrs. Wiggins (from Dr. Seuss' The Lorax) as Jackie Seville
- Once-ler (from Dr. Seuss' The Lorax) as Toby Seville