• Eric Cartman as Horrid Henry (Cartman and Henry are both villains)
  • Stan Marsh as Perfect Peter (Stan and Peter are both the main heroes of the series)
  • Mr. Garrison as Henry's Dad
  • Carol McCormick as Henry's Mom
  • Damien as Rude Ralph
  • Shelly Marsh as Moody Margaret
  • Mrs. Crabtree as Sour Susan
  • Chef as Beefy Bert
  • Token Black as Brainy Brain
  • Tweak Tweek as Anxious Andrew
  • Tammy Warner as Lazy Linda
  • Stuart McCormick as Greedy Graham
  • Wendy Testaburger as Gorgeous Gurinder
  • Liane Cartman as Rich Aunt Ruby
  • Clyde Donovan as Stuck-Up Steve
  • Bebe Stevens as Prissy Polly
  • Stephen Stotch as Pimbly Paul
  • Randy Marsh as Mr. Mossy
  • Sharon Marsh as Mrs. Mossy
  • Kyle Broflovski as Goody-Goody Gordon (Kyle and Gordon are both best friends to Stan and Peter)
  • Craig Tucker as Tidy Ted
  • Butters Stotch as Spotless Sam
  • Shelia Broflovski as Miss Battle-Axe
  • Kenny McCormick as Weepy William
  • Gerald Broflovski as Big Boss
  • Principal Victoria as Miss OddBod
  • Gregory Of Yaredale as Slimmy Sammy
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