Cast[]
- Mario as Megamind
- Yoshi as Minion
- Luigi as Metroman
- Bowser as Hal Stewart/Tighten
- Peach as Roxanne
- Bowser Jr. as Prisoner
- Wario & Waluigi as The Prison Gruads
- Lanky Kong as Newscaster
- Toadette as Lady Scott
- Toad as Lord Scott
- Baby Mario as Baby Megamind
- Baby Luigi as Baby Metro Man
- Baby Yoshi as Baby Minion
- Baby Peach as Baby Roxanne
- Young Mario as Young Megamind
- Young Luigi as Young Metro Man
- Young Yoshi as Young Minion
- Young Peach as Young Roxanne
- Donkey Kong as Megamind's Dad
- Candy Kong as Megamind's Mom
- Chunky Kong as Bernard
- Roy "Bully" Koopa as Destruction Worker
- Ludwig "Kooky" Von Koopa as Psycho Delic
- Wendy "Kootie Pie" O Koopa as Hot Flash