- Bugs Bunny (voiced by Billy West): an anthropomorphic gray hare, famous for his relaxed, passive personality, pronounced Mid-Atlantic accent, depiction as a mischievous trickster and his catchphrase "Ehh, what's up, doc?".
- Daffy Duck (voiced by Dee Baker): Bugs Bunny's best friend, who is depicted as a crazy prankster, but at the same time, arrogant, greedy and naïve. His catchphrases are "You're desthpicable" and his laugh "Woo-hoo!".
- Lola Bunny (voiced by Kristen Wiig): Bugs Bunny's wife. Like Bugs, she is a sadistic trickster, besides having a mixture of tomboyish and eccentric traits and an affinity for basketball and similarly to her boyfriend, she often finds herself in situations of extreme danger. Her catchphrase is "Don't ever call me doll".
- Porky Pig (voiced by Bob Bergen): Daffy Duck's sidekick. He's commonly depicted as smarter than Daffy, being his voice of reason, and an innocent explorer who is especially known by his stutter. His catchphrase is "Th-th-th-that's all folks!".
- Squeaks Squirrel (voiced by Scott Menville): a big-nosed orange-colored squirrel with a big and thin tail and buckteeth in his upper jaw, being Bugs Bunny's sidekick and sometimes companion in his adventures. He doesn't speak, instead communicating through squeaks and chirps, while occasionally giving way to near intelligible speech.
- Buster Bunny (voiced by Chuck Adler): a young male rabbit and the leader of the Tiny Toons. He has to deal with the challenges of a tough school curriculum, the machinations of Montana Max and the advances of Elmyra Duff. Like Babs, he will do anything for a laugh, though he is marginally more sane and calm than his female counterpart. His hero and mentor is Bugs Bunny.
- Plucky Duck (voiced by Eric Bauza): a greedy, egotistical, hyperactive young duck who will often engage in various schemes with the goal of either personal glory or satisfying some personal whim, very similar to Daffy Duck, his mentor. In spite of his many faults, Plucky does have genuine goodwill.
- Yakko Warner (voiced by Rob Paulsen): the eldest of the Warner siblings who is commonly depicted as a fast talking smart aleck reminiscent of Groucho Marx.
- Wakko Warner (voiced by Jess Harnell): the middle child of the Warner trio who has a huge appetite and a "gag bag" filled with tricks.
- Sylvester Pussycat (voiced by Bill Farmer): a tuxedo cat that shows much pride and plenty of envy and he also never gives up, despite failing various times, being mainly paired with Tweety, Speedy Gonzales, Hippety Hopper and Sniffles. His catchphrase is "Sufferin' succotash".
- Tweety Bird (voiced by Eric Goldberg): a yellow canary that has a somewhat large head. Despite being naïve, he usually acts in a violent way when a cat (mainly Sylvester, Sylvia, Junior, Penelope, Claude Cat or Babbit and Catstello) tries to eat him, which ends up in Tweety attacking them. His catchphrase is "I tawt I taw a puddy tat. I did, I did taw a puddy tat".
- Hamton Pig (voiced by Billy West): a young pig with his personality dominated by tendencies toward being bookish and obsessively neat. When Hamton's patience is pushed too far, however, he is known for angry fits that surprise the source of his frustration. His mentor is Porky Pig, despite lacking a stutter.
- Dot Warner (voiced by Tress MacNeille): the youngest and only female of the Warner siblings, who is cute, pretty and sassy, and uses her apparent innocence to manipulate and torment those who stand in her and her brothers' way.
- Slappy Squirrel (voiced by Sherri Stoner): an aging movie star squirrel, who seems to enjoy whacking people with her purse and using high explosives, the more the better.
- Babs Bunny (voiced by Tress MacNeille): a young and very beautiful pink and white female rabbit, who wears a yellow medium-sleeved blouse, short pale purple knee-length skirt and purple bowed ribbons near the tips of her ears, being a female performer who will do nearly anything for a laugh. Unlike the original show, her mentor is Lola Bunny.
- Elmer Fudd (voiced by Jeff Bergman): Bugs’ main frenemy. His aim is to hunt both Bugs and Daffy, but he usually ends up seriously injuring himself and/or other antagonizing characters. He speaks in an unusual way (rhotacism), replacing his Rs and Ls with Ws. Elmer's signature catchphrase are "Be vewy vewy quiet, I'm hunting wabbits" and his laugh "Huh-huh-huh-huh!".
- Yosemite Sam (voiced by Fred Tatasciore): Bugs’ archenemy. He's a more violent and competent enemy than Elmer, given that Sam has a tougher accent, a higher fierce voice, and a more violent spirit. His catchphrases are "Ya long-eared galoot!" and "I hates rabbits".
- Elmyra Duff (voiced by Cree Summer): an adorable, young, sweet and very beautiful 12-year-old red-headed female human character. She is based superficially on her name derivative, Elmer Fudd, being her mentor and uncle. Despite her sweetness and beauty, Elmyra is quite young and obsessed with animals and cute things, unlike Elmer. Like the final season of Pinky and the Brain, she's the owner of Pinky and the Brain.
- Pinky Mouse (voiced by Eric Bauza): an imbecilic white mouse who accompanies Brain in his doomed attempts for world conquest.
- Brain Mouse (voiced by Maurice LaMarche): Pinky’s genius companion and the Warners’ nemesis, who continuously launches attempts to take over the world. However, something always goes wrong with his plans.
- Montana Max (voiced by Daniel Cooksey): the megalomaniacal owner of the ACME corporation, who has a persona like his mentor Yosemite Sam, having crimson hair, a violent temper and a hatred for certain rabbits (Buster and Babs), being a spoiled, rich boy who lives in a huge mansion at the far edge of ToonTown and treating everybody badly, having no friends to put up with him.
- Wile E. Coyote (voiced by J.P. Karliak): a coyote who utilises absurdly complex gizmos (often from the ACME Corporation) and elaborate plans to try to catch his prey, considering himself a "Super Genius" (his catchphrase), rather than his natural guile, but fails every time.
- Road Runner (voiced by Kevin McDonald): a greater roadrunner characterised by his speed and his catchphrase “Beep, Beep!”. Unlike other Looney Tunes content, he is fully able to communicate in fluent sentences which are often sped up.
- Bobby Pigeon (voiced by John Mariano): the de-facto lead pigeon of the Goodfeathers - spoofing Robert DeNiro. He tends to avoid the daily arguments between his subordinates, but sometimes gets a laugh out of them.
- Pesto Pigeon (voiced by William Salyers): Bobby’s right hand pigeon - spoofing Joe Pesci. He often gets into scuffles with Squit after being called via various endearment terms, which is not even helped by his short temper.
- Squit Pigeon (voiced by Matthew Broderick): The rookie of the Goodfeathers - spoofing Ray Liotta. Despite his good natured dispotion, he always gets abused by Pesto for his innocence.
- Tazmanian Devil (voiced by Jim Cummings): commonly nicknamed as Taz, he's generally portrayed as a dim-witted teenager-type with a notoriously short temper and has little patience. He will eat anything and everything, with an appetite that seems to know no bounds, being best known for his speech consisting mostly of grunts, growls, rasps and screeches and his ability to spin and bite through just about anything.
- Foghorn Leghorn (voiced by Jeff G. Bennett): a rooster known by his Virginian accent, "good ol' boy" speaking style, and a penchant for mischief, having a knack of saying "I say" as a form of interjection in his speech.
- Sniffles Mouse (voiced by Andrea Libman): a little, sweet and smart, but naïve, brown mouse that is commonly in trouble. Despite his cutenness, he sometimes acts in a violent way (similarly to Tweety) when a cat (mainly Sylvester, Sylvia, Junior, Penelope, Claude Cat or Babbit and Catstello) tries to eat him, being also characterized as an incessant chatterbox who serves as a annoying nuisance.
- Beaky Buzzard (voiced by Bill Fagerbakke): a lanky buzzard with black body feathers and a white tuft around his throat, having a long and thin neck, bending halfway at an enormous adam's apple. He's characterized as childlish, clumsy, goofy and dumb, but sometimes smart and mischievous. His catchphrase is "Oh no no no".
- Dizzy Devil (voiced by Maurice LaMarche): commonly nicknamed as Diz, he’s generally portrayed as a childish schoolboy type with a notorious taste for partying and has little intelligence. He will eat anything and everything, with an appetite more voracious than his mentor, Tazmanian Devil, being best known for his speech, which is much more advanced due to him being able to grasp human language, and just like Taz, he can spin and bite through anything.
- Buttons Hound (voiced by Gregg Berger):a heroic yet unlucky Lassie-esque hound who has the karmic job of protecting Mindy, even at the cost of severe injury to himself.
- Mindy (voiced by Nancy Cartwright): a mischievous little girl whom Buttons has sworn to protect.
- Furball Cat (voiced by Eddie Fitzgerald): a blue male cat who is unlucky and spends most of his time trying to eat Sweetie Bird and Sneezer Mouse or being chased by a lovestruck Fifi la Fume. Unlike the original show, he’s owned by Mary Melody and is able to speak.
- Speedy Gonzales (voiced by Fred Armisen): nicknamed "The Fastest Mouse in all of Mexico", his major characteristics are the ability to run extremely fast and speaking with an exaggerated Mexican accent. His catchphrase is "Andale! Andale! Arriba! Arriba!".
- Pepé Le Pew (voiced by Maurice LaMarche): a French skunk known by his continuous in search of romance, but his scent, self-delusion and his overly persistent manner inhibit his efforts. His main aim is Penelope Pussycat, but he also chases other characters that accidentally got into white paint. His catchphrase is "Vive l'amour!".
- Gogo Dodo (voiced by Howard Mandel): a young green male dodo with blue shoes, a purple collar, and a pink and purple umbrella sticking out from the top of his head, being noted for performing various bizarre sight gags or stunts. Furthering this end, Gogo made his home in the Daliesque realm known as Wackyland, a surreal land where backgrounds change constantly.
- Rita Cat (voiced by Bernadette Peters): a singing cat who travels with Runt in search for a comfortable home. She has a pessimistic view on existence, and finds humans to be very untrustworthy.
- Runt Mutt (voiced by Franklin Welker): a big, scruffy mutt who is loyal and friendly, yet stupid due to the fact that he thinks Rita is a dog.
- Barnyard Dawg (voiced by Mark Hamill): a Basset Hound who is depicted as Foghorn’s protective, hardworking, quick-tempered, intelligent, relaxed, easygoing, serious, truthful, and honest frenemy.
- Yogi Bear (voiced by Dave Fouquette): an anthropomorphic grizzly bear, famous for his gluttonous, deceptive personality, pronounced Ed Norton accent, depiction as a wisecracking escapist and his penchant for picnic baskets.
- Booboo Bear (voiced by Tom Kenny): a diminutive, cautious bear cub with an indigo bowtie, being Yogi Bear’s sidekick and right paw bear. He prefers not to steal picnic baskets, instead following Ranger Smith’s rules.
- Ranger J. Smith (voiced by J.P. Karliak): Yogi’s main frenemy. His aim is to prevent Yogi from eating from ill-gained picnic baskets, but he usually ends up being friends with him and/or lets him escape unknowingly. He has a profound hobby of creating rules for the park creatures to follow, which irritates Yogi to no end.
- Cynthia Bear (voiced by Carolyn Lawrence): Yogi Bear’s wife. Unlike Yogi, she is more sensitive than him, having feminine traits and an affinity for romancing with him. Similarly to her husband, she sports a skirt and parasol whereas Yogi wears a porkpie hat and necktie.
- Scoobert D. Doo (voiced by Franklin Welker): the mascot of Mystery Incorporated who is a cowardly Great Dane that speaks in broken English.
- Norville Rogers (voiced by Matt Lillard): Scoobert’s equally cowardly best friend who has a big appetite and a distinctive 60s’ speech dialect.
- Huck Hound (voiced by Jeff Bergman): Yogi Bear’s best friend, who is commonly depicted as more sensible than him, being his more relaxed foil, and a clumsy workman specially known by his Southern drawl.
- Quickdraw McGraw (voiced by Maurice LaMarche): Yogi Bear’s close friend, being depicted as a well intentioned sheriff, but at the same time, dimwitted, ignorant, and stupid.
- Baba Looey (voiced by Dino Andrade): Quickdraw McGraw’s faithful deputy, his major characteristics are his oversized sombrero and exaggerated Brazilian-Mexican accent.
- Snagglepuss (voiced by Jim Cummings): a mountain lion known by his continuous pursuit of stardom, but his mannerisms, Lahr based accent, and his overly persistent nemesis, Major Minor, often inhibit his efforts. His other main aim is a more habitable cavern, but he always ends up where he started whenever he tries to clean it.
- Hokey Wolf (voiced by Michael McDonald): a wolf known by his Phil Silvers accent, a smooth talking style, and a knack for mooching off of others’ property, being smart enough to fool those he comes across.
- Dingaling Wolf (voiced by Eric Bauza): a miniature wolf who is Hokey’s submissive, mindless, gullible, helpful, naïve sidekick and travelling companion.
- Augie Doggie (voiced by Patrick Zimmerman): Doggie Daddy’s son, being basically a miniature version of his father, having a large head in proportion to a small body. Unlike his father, he’s a lot more rambunctious and wears a green jumper, being noted saying that he is very intelligent.
- Doggie Daddy (voiced by Neil Kaplan): a dachshund that shows much warmth, and plenty of smoothness and also tries to please his son in any way possible, despite being strict towards him.
- Thomas Cat (voiced by Jim Cummings): a bluish Grey housecat and the roommate of Jerry. He often has to deal with his job of keeping out the pests (that means Jerry), the abuse of Spike and his own overbearing ego. When his owners Rick and Ginger are home, he often takes pleasure in bullying Jerry Mouse, though usually because he has to. Like his 1992 incarnation, he speaks in the show.
- Jerry Mouse (voiced by Billy West): a fleetfooted, jovial, and intelligent mouse who will often engage in causing interruptions in Tom’s life with the goal of either abusing him or tricking him into being pummelled by Spike. In spite of his rivalry with Tom, the two often become friends.
- Yakky Doodle (voiced by Samuel Kwasman): a baby mallard that has a Donald Duck esque vocal. Despite being young, he is usually rescued by Chopper Bulldog when he gets captured by Fibber Fox, culminating with Chopper abusing the fox.
- Chopper Bulldog (voiced by Rick Zieff): the farm bulldog and Yakky’s protector. Due to his own laziness, Fibber Fox and Alfy Gator are always outwitting him. However, when he discovers that Yakky has been kidnapped, he ends up attacking them.
- Pixie Mouse (voiced by Bob Bergen): a mouse who wears a blue bowtie and Dixie’s more sophisticated brother.
- Dixie Mouse (voiced by Jack McBrayer): a mouse clad in a red jacket who has a pronounced Dixie accent, hence his name.
- Mister Jinks (voiced by Jon Benjamin): a ginger cat that has a stereotypical valleyperson accent. Despite knowing of the philosophy that cats aren’t supposed to fraternise with mice, he still has a friendship with Pixie and Dixie, whilst hypocritically saying his catchphrase "I hate those meeces to pieces".
- Super Snooper (voiced by Rob Paulsen): a tomcat detective who utilises his gumshoo instincts, to solve the case he has been given, having an Ed Gardner esque accent, rather than his cat like reflexes.
- Blabber Mouse (voiced by Gregg Berger): a mouse detective characterised by his lisp and his role as Snooper’s assistant.
- Optimus Prime (voiced by Pete Cullen): the commander of the Autobots, famous for his wise, protective personality, tractor trailer alternate mode, depiction as a legend amongst his fellow Cybertronians, and his motto "Freedom is the right of all sentient beings".
- Megatron (voiced by Franklin Welker): the leader of the Decepticons. His aim is to someday return to Cybertron, but not before destroying the entirety of Autobotkind. He believes in a philosophy that the only way of living is through brutality, strategy, ruthlessness, cunning and terror. His motto is "Peace through tyranny".
- Bumblebee (voiced by Jerry Levy): the spy for the Autobots. He’s usually portrayed as more courageous than the other members of his faction, being their biggest fan and a stealthy weakling who is especially known by his earth car alternate mode. His motto is "The least likely can be the most dangerous".
- Ratchet (voiced by Jeff Combs): the Autobot medic, known by his can-do attitude, double role as a repairman, penchant for having fun, and his motto "You’ll break it, I’ll remake it".
- Starscream (voiced by Tom Kenny): the air commando for the Decepticons. He’s a more scheming and conceited fighter than Megatron, given that Starscream has an ill-gotten dose of vanity, speed unmatched by the other Decepticons, and a deluded belief that he should be top Con. His motto is "Conquest is made of the ashes of one’s enemies".
- Soundwave (voiced by Jeff G. Bennett): the Decepticons’ communications officer. Soundwave is not very popular amongst the other Cons, but is often useful in eavesdrop missions, often accompanied by his pet condor Laserbeak and sometimes by Ravage and Rumble. His motto is "Cries and screams are music to my ears".
- Wheeljack (voiced by Jeff Bergman): the Autobots’ mechanical engineer, being portrayed as a mad scientist, but at the same time, selfish, cocky, and accident prone. His motto is "Never do what your enemy expects you to do".
- Prowl (voiced by Jonny Rees): the Autobots’ military strategist that shows much logic and plenty of diligence and he also strives to find reason for anything, despite having a dislike for conversation. His motto is "Logic is the ultimate weapon"
- Thundercracker (voiced by Roger C. Smith): a Decepticon warrior who shares some similarities with his half-cousin Starscream, mainly having most of his exterior looks. Unlike him, he commonly has his doubts about the Decepticon cause. Also, like Starscream and the other Seekers, Thundercracker has unmatchable speed. His motto is "The deadliest weapon is terror".
Felix the Cat
- Felix Cat (voiced by Thom A. Hernandez): an anthropomorphic black cat, famous for his adventurous, wily personality, magic bag of tricks, depiction as the first toon to ever exist and his catchphrase "Righty-o"
- SpongeBob Squarepants (voiced by Tom Kenny): an anthropomorphic sea sponge, famous for his loyal, optimistic personality, astounding frycook skills, depiction as a childish everyman, and his misleading curiosity.
- Patrick Star (voiced by Bill Fagerbakke): SpongeBob’s best friend. He’s commonly depicted as more laid back than SpongeBob, being his voice of ignorance, and a village idiot who is especially known for living under a rock.
- Squidward Tentacles (voiced by Rodger Bumpass): SpongeBob’s neighbour, being depicted as a "creative genius", but at the same time, impatient, condescending, and serious.
- Mister E. H. Krabs (voiced by Clancy Brown): a crab that shows much greed and plenty of avarice, and is also the owner of the Krusty Krab, despite endearing his daughter Pearl, and finding SpongeBob’s antics infuriating.
- Sheldon Plankton (voiced by Mister D. Lawrence): Krabs’ rival. His aim is to steal the secret formula for Krabby Patties to better his business, but he usually ends up getting splattered by the residents of ToonTown’s waters. He has an extremely grumpy and irritable personality (actually his determination) due to being bullied for his size.
- Karen Plankton (voiced by Jillian Talley): Plankton’s wife. She’s a more calculating and competent antagonist than her husband, given that Karen has a stereotypical valley girl accent, an analytical personality, and a more romantic spirit.
- Sandra Cheeks (voiced by Carolyn Lawrence): SpongeBob’s love interest. Unlike SpongeBob, she is an adventurous tomboy, besides being a squirrel and having an affinity for fitness and similarly to SpongeBob, she often has an optimistic disposition.
- Miss P. Puff (voiced by Mary J. Catlett): Krabs’ girlfriend, she’s a wise, deadpan, sensible, yet sometimes unstable pufferfish. The boating instructor for Bikini Bottom, she tends to downgrade SpongeBob whenever he fails his boating exams, which happens quite often due to her extremely sensitive body being able to inflate.
- Pearl Krabs (voiced by Lori Alan): Krabs’ adopted daughter. She’s a typical sperm whale, though due to her immense size, she finds it difficult to fit in with the other Bikini Bottomites, but gets along with most toons due to her status as a mammal. When not with her father, she is commonly found shopping for compact discs of her favourite boybands.
- Gary Wilson (voiced by Dee Baker): a cultured sea snail with a gramophone hidden in his shell at all times, being SpongeBob’s housepet and constant companion. He dosen’t speak, instead communicating in a half cat, half human dialect.
- Garfield Cat (voiced by Franklin Welker): an anthropomorphic ginger cat, famous for his lazy, cynical personality, massive appetite, depiction as a sarcastic jerk, and affection for lasagna.
- Odie Beagle (voiced by Gregg Berger): Garfield’s best friend. He’s commonly depicted as one of the dumbest toons in town, being Garfield’s punching bag and having knowledge of only one thing - play. He speaks in a half dog, half human dialect.
- Orson Pig (voiced by Sean Astin): a pig that shows much intelligence and plenty of common sense and is also the elder of the farm, despite having an overactive imagination whilst reading.
- Booker Chick (voiced by Bob Bergen): Orson’s adopted son, being basically a chick who imprinted on him since birth, having never known his real mother at all. However, unlike Orson, he’s a lot more feisty and has a lust for adventure, being noted that he’s just been born.
- Sheldon Egg (voiced by Daniel Milano): Booker’s younger brother that resides in an egg. Despite being near hatched, he fears that he will never be ready to evolve into a chick anytime soon, which is probably never.
- Roy Rooster (voiced by David P. Smith): Orson’s best friend, being depicted as a mischievous irritant, but at the same time, lovable, slothful, and reckless.
- Wade Duck (voiced by Cameron Clarke): a duck known by his panophobia, a sentient inner tube which he wears constantly, having a knack for checking his surroundings, and being prone to panic.
Ren and Stimpy
- Ren Höek (voiced by Billy West): an asthma hound chihuahua, famous for his hyperactive, abusive personality, pronounced Peter Lorre accent, depiction as an unstable lunatic and his catchphrase "You eediots!".
- Stimpy Catoogan (voiced by Eric Bauza): Ren’s sidekick. He’s commonly depicted as more genial than Ren, being his civil partner, and a dimwitted oaf especially known for his constant saying of "Happy, Happy, Joy, Joy".
- George Liquor (voiced by Clancy Brown): Ren and Stimpy’s tyrannical owner. He claims to be a respectful American citizen, but is actually an extremely patriotic bigot. He believes in a strange myth that all Republicans are in fact Communists. His catchphrase is "Hi, I’m George Liquor, American!"
- Jimmy Liquor (voiced by Franklin Welker): a teenage boy known by his extremely low iQ, and his own family, consisting of George Liquor, and his cousins Ernie & Slab, only make his condition worse. His main love interest is Sody Pop, but George liquor constantly prevents them from seeing each other.
- Powdered Toast Man (voiced by Michael Keaton): a toast-based superhero known by his constant flatulence, false identity as a vicar named Pastor Toastman, a dramatic speaking style, and having a knack of flying backwards.
- Cigarettes Cat (voiced by Eddie Fitzgerald): Jimmy’s pet cat, being depicted as an easygoing jerk, but at the same time, cowardly, feral, and naive.
- Mighty Mouse (voiced by Pat Pinney): a rodent superhero, whose personality is similar to that of Superman, which makes him somewhat of an icon of the rodent populace of ToonTown, besides Mickey Mouse, Jerry Mouse and Skidoo Mouse.
- Harlem S. Cat (voiced by J. Timberlake): a black cat that constantly wears glasses. Despite being small in stature, he has been known to sing in a smooth pop tenor vocal range whenever he is on stage. His theme song is the Harlem Shuffle.
- Ernie Liquor (voiced by Gabe Swarr): Slab’s older brother. He wears a lime t-shirt and the more sensible of the duo.
- Slab Liquor (voiced by Dee Baker): George Liquor’s younger nephew who wears a blue t-shirt and has a tremendous stroke of bad luck.
- Sody Pop (voiced by Janice Kawaye): Jimmy’s love interest. She’s a typical teenage female, though for some reason or another, she is overaged to be Jimmy’s significant other and is usually kicked out by George. When not with him, she likes to wear underused lingerie.
- Dirty Dog (voiced by Nick Kroll): Ren and Stimpy’s archenemy. He’s a more megalomaniacal and formidable antagonist than George, given that Dirty has the vocal chords of Robert Ryan, a long history of ex-wives, and a more perverted spirit.
- Jonathan Bravo (voiced by Jeff G. Bennett): a muscular ladies man in training, famous for his pretentious, slovenly personality, pronounced Presley accent, depiction as a delusional stalker and his extremely powerful range of fighting styles.
The Grim Adventures of Billy & Mandy
- Grim (voiced by Gregory Eagles): an Undead personification of death, famous for his dour, pessimistic personality, pronounced Jamaican accent, depiction as an overworked slave for hire, and his legendary scythe.
- Billy (voiced by Richard S. Horvitz): Grim’s only friend. He’s commonly portrayed as more stupid than Grim, being his voice of comfort, and a happily naive youngster particularly noted for his humongous nose.
- Mandy (voiced by Grey D. Griffin): Billy’s love interest. Despite being a couple, the two have different personalities, with Mandy being dominant towards Billy and sometimes being abusive towards him.
- Irwin Dracula (voiced by Vanessa Marshall): Billy’s sidekick, being depicted as a vampiric nerd, but at the same time, cowardly, awkward and power hungry.
- Frederick Fredburger (voiced by Carlson H. Greenblatt): a baku characterised by his immaturity and his inability to spell.
- Hoss Delgado (voiced by Diedrich Bader): Grim’s nemesis. His aim is to exterminate Grim for good, but his strained relationship with Eris weakens his resolve to do so. His right hand is metal gauntlet which he can turn into a chainsaw at will. His catchphrase is "I’ll teach you to mess with the living!".
- Jeffrey Spider (voiced by Max Atoms): commonly named as Jeff, he’s generally portrayed as a genial everyman-type with a notoriously friendly demeanour and has little animosity. He will pay a visit to Billy anytime and everytime, due to the fact that he views Billy as his own dad, having imprinted on him since his birth.
- Hector con Carne (voiced by Philip LaMarr): a villainous sentient brain. He’s a more charismatic threat than Hoss, given that Hector has a Mexican accent, a deeper vocal, and a more refined spirit.
- Boskov Bear (voiced by David Fennoy): a Russian circus bear and Hector’s body. Due to his stupidity, Hector is usually able to take advantage of him for his own deeds. However, when his meal is confiscated from him, he ends up in a rage. Unlike other Billy and Mandy media, he speaks in a Russian accent in the show.
- General R. P. Skarr (voiced by Armin Shimerman): the tactical genius of Evil con Carne who utilises his own intelligence and dry wit to try and overthrow Hector, rather than feigning loyalty to him, but fails everytime.
- Major Doctor A. J. Ghastly (voiced by Mandy Leighton): The scientist for Evil con Carne. She’s a typical evil chemist, though by some means or another, her machinations prove to be utterly futile, and is the wife of Hector con Carne. When not with him, she is often seen working other villains like Zim, Dick Dastardly, Plankton, etc.
Rocko’s Modern Life
- Rocko Rama (voiced by Carlos Alazraqui): an anthropomorphic wallaby, famous for his practical, neurotic personality, pronounced Australian accent, depiction as a neat freak, and his catchphrase "(blank) day is a very dangerous day".
- Heff Wolfe (voiced by Tom Kenny): Rocko’s best friend, being depicted as an overgrown slob, but at the same time, loyal, gluttonous, and caring. His catchphrase is "That was a hoot!"
- Filburt S. Turtle (voiced by Mister D. Lawrence): Rocko’s sidekick. He’s commonly depicted as less sane than Rocko, being his voice of immaturity, and a nauseous hypochondriac especially known by his Jewish accent. His catchphrase is "I’m nauseous".
- Ed Bighead (voiced by Chuck Adler): Rocko’s next door neighbour. His aim is to dispose of Rocko for good, but he usually ends up failing everytime he tries to do so. He is currently the Chief Executive Officer of Conglom-O. His catchphrase is "I hate my life."
- Bev Bighead (voiced by Harv Fierstein): Ed’s wife. She’s a more maternal and caring toon than her husband, given that Bev has a New Yorker accent, a lower, raspy vocal, and a more friendly spirit. Her catchphrase is "Oh Ed!"
- Chuck Chameleon (voiced by Jaime Camil): Leon’s brother who is more conniving and has a Scandinavian accent.
- Leon Chameleon (voiced by Eric Bauza): Chuck’s brother who is adept at filmmaking, has a long list of odd jobs, and a habit of accidentally rubbing people the wrong way.
- Eric Cartman (voiced by Trey Parker): an obese 10 year old 3rd grader, famous for his corrupt, spoiled personality, self absorbed demeanour, depiction as a wannabe tyrant, and hatred for Jews.
- Stanley Marsh (voiced by Jason Ritter): Cartman’s sidekick, being portrayed as a sensitive straight man, but at the same time, resourceful, moralistic and rational.
- Kenneth McCormick (voiced by Matthew Stone): Cartman’s best friend. He’s commonly depicted as poorer than Cartman, being his voice of sympathy, and a slovenly redneck who is especially known for his high death and immortality rates.
- Kyle Broflovski (voiced by Robert Moynihan): a 10 year old Jewish boy who shows much intelligence and plenty of impatience. He also often speaks out against bigotry, being pitted against Cartman as his bitter rival.
Cow and Chicken
- Cow (voiced by Chuck Adler): an anthropomorphic cow, famous for her friendly, amicable personality, childish voice, depiction as an emotional schoolgirl, and her secret identity as SuperCow.
- Chicken (voiced by Billy West): Cow’s older brother, being depicted as a pessimistic egotist, but at the same time, intelligent, moralistic, and hypocritical.
- Red Guy (voiced by Andrew Richter): one of ToonTown’s many representations of Hell. His aim is send both Cow and Chicken to eternal damnation, but he usually ends up failing due to his incompetent flamboyance. He owns a large assortment of costumes which he constantly wears to better his image.
- Homer Simpson (voiced by Daniel Castellaneta): the Simpson patriarch, famous for his lazy, ignorant personality, penchant for booze, depiction as a middle class factory worker, and his catchphrase "D’oh!".
- Bartholomew Simpson (voiced by Nancy Cartwright): Homer Simpson’s son, being depicted as a dangerous delinquent, but at the same time daring, comical, and well meaning.
- Marjorie Simpson (voiced by Julie Kavner): Homer Simpson’s wife. Unlike Homer, she is a disciplined homemaker, besides having secretly cheated on him and an affinity for moral value. Similarly to her husband, she often starts politically correct movements.
- Lisa Simpson (voiced by Yeardley Smith): Bart Simpson’s sister. She’s commonly depicted as smarter than Bart, being his voice of knowledge and an extremely intelligent person known by her iQ of 159.
- Mickey Mouse (voiced by Christopher Diamantopoulos): the leader of the Traditional toons. Mickey is an anthropomorphic rubberhose mouse, famous for his mischevous, brave personality, cheery falsetto, depiction as a plucky rascal and his catchphrase "See ya real soon!".
- Minerva Mouse (voiced by Grey Griffin): Mickey Mouse’s wife. Like Mickey, she’s an impulsive scoundrel, besides having more feminine traits and an affinity for hats and hairbows. Similarly to her husband, she often finds herself in situations of extreme peril.
- Pluto Pup (voiced by Billy West): a slender gold coloured bloodhound with black ears and a brown collar, being Mickey Mouse’s pet and constant companion. Unlike other media featuring the Fabulous Five, he speaks in the show.
- Donald Duck (voiced by Dan Ross): Mickey’s sidekick, being depicted as a foul tempered fowl, but at the same time, unlucky, seafaring, and misunderstood.
- Goofy Goof (voiced by Bill Farmer): Mickey’s best friend. He’s commonly depicted as more dim than Mickey, being his voice of geniality, and a clumsy fellow especially known for doing odd jobs around town.
- Daisy Duck (voiced by Tress MacNeille): Donald Duck’s wife. In contrast to Minnie, she is vain, sophisticated, talkative and frivolous, acting as a straight character who tends to be dominant over Donald.
- Bender Rodriguez (voiced by John DiMaggio): a bending unit robot, famous for his chaotic, existentialist personality, hidden Mexican heritage, depiction as an alcohol fuelled foulmouth, and his catchphrase "Bite my shiny metal ass!".
- Phil Fry (voiced by Billy West): Bender’s best friend, being depicted as a lazy slacker, but at the same time, friendly, sensitive, and cowardly. His catchphrase is "Shut up and take all my money!".
- Leela Turanga (voiced by Kate Sagal): Fry’s wife. In contrast to her husband, she is tomboyish, sexy, attractive, and tough, but similar to Fry’s lazy and genial personality, she has a painfully sensitive past which she hides from the other toons.
- Dexter (voiced by Candyce Milo): an intelligent science major, famous for his inventive, tentative personality, pronounced Russian accent, depiction as a boy genius, and rivalry with his sister, Dee Dee.
Kids Next Door
- Nigel Uno (voiced by Ben Diskin): the leader of the Kids Next Door Virginia Sector, famous for his uptight, awkward personality, pronounced British accent, depiction as a bald scapegoat, and his catchphrase "Kids Next Door, battle stations!".
- Hoagie Gilligan (voiced by Eric Bauza): Nigel Uno’s best friend, being depicted as a skilled technologist, but at the same time, cheesy, goofy, and witty.
- Kuki Sanban (voiced by Laura Tom): Wally Beatles’ girlfriend. Despite being depicted as a couple, the two sometimes have their squabbles, with Kuki being unhealthily affectionate towards Wally, and sometimes tending to smother him.
- Wally Beatles (voiced by Dee Baker): Hoagie Gilligan’s best friend. He’s commonly depicted as more dumber than Hoagie, being his voice of realism, and a hardened combatant, who is especially known by his Australian accent.
- Abby Lincoln (voiced by Cree Summer): Hoagie Gilligan’s girlfriend. In contrast to Kuki, she is calm, sensible, level headed, and smart, but similarly to Kuki’s character, she has moments of awkwardness and she tends to be dominant over Hoagie.
- Captain Popeye (voiced by Tom Kenny): a hulking sailorman, famous for his slovenly, unassuming personality, pronounced seaman accent, depiction as a toughened underdog, and his secret weapon: spinach.
My Life as a Teenage Robot
- Jennifer Wakeman (voiced by Janice Kawaye): a female teenage robot, famous for her eager, tomboyish personality, pronounced Tamachi accent, depiction as a vigilant crimefighter, and desire to become a normal teenager.
- Bradley Carbunkle (voiced by Chad Doreck): Jennifer’s best friend, being depicted as an unrepentant ladies man, but at the same time, adventurous, cheesy, and reckless.
- Tucker C. Carbunkle (voiced by Audrey Wasilewski): Bradley’s younger brother. He’s commonly depicted as more hyperactive than his brother, being his voice of paranoia, and an excitable youngster especially known for his role as a nuisance.
- Samurai Jack (voiced by Philip LaMarr): a legendary samurai, famous for his stoic, altruistic personality, pronounced Japanese accent, depiction as a genial sage, and his catachphrase "Got to get back, back to the past".
Ed, Edd n Eddy
- Edwin (voiced by Matthew Hill): the powerhouse of the Eds, being portrayed as an utter goof, but at the same time, positive, forgetful, and friendly.
- Eddward (voiced by Sam V. Khouth): the brains of the Eds. He’s commonly depicted as more genial than Eddy, being his voice of logic and a weakling especially known for his nickname of Double D.
- Eddy (voiced by Tony Sampson): the leader of the Eds, famous for his desperate, unscrupulous personality, pronounced teenage voice, depiction as a tactical scam artist, and adoration for jawbreakers.
- Woody Woodpecker (voiced by Eric Bauza): anthropomorphic acorn woodpecker, famous for his heckling, screwy personality, annoyingly high pitched laugh, depiction as a deranged moocher, and his catchphrase "Guess who!".
- Finn Mertens (voiced by Jerry Shada): Jake’s adoptive brother, being depicted as a legendary adventurer, but at the same time, impulsive, responsible, and moralistic. His catchphrase is "It’s Adventure Time!".
- Jake the Dog (voiced by John DiMaggio): an anthropomorphic shapeshifting dog, famous for his wisecracking, laid back personality, gruff vocal demeanour, depiction as Finn’s wise sidekick, and taste for bacon pancakes.
- BeMOre (voiced by Niki Yang): Finn and Jake’s pet console. He’s commonly depicted as more random than his masters, being their voice of immaturity and a friendly dork who claims not to have emotions.
- Bonnibel Bubblegum (voiced by Heidi Walch): The leader of the Candy Kingdom who shows much goodness and plenty of dark humour and she also possesses a great sense of judgement, being mainly the mortal enemy of Ice King.
- Marceline the Vampire Queen (voiced by Olive Olson): Bonnibel’s wife, she’s a fearless, daring, mischievous, but sometimes malevolent trickster. Similarly to her first appearance, she tends to be more antagonistic towards other toons, mainly Finn and Lion-O, and sometimes gets attacked by them in return.
- Ice King Petrikov (voiced by Tom Kenny): the antiquarian monarch of the Ice Kingdom. His main aim is to force Princess Bubblegum into matrimony, but his social anxiety and permanent memory loss often prevent him from doing so. He keeps a pet penguin named Gunther, who is the leader of the tens of thousands of penguin servants of the Ice King.
- Lumpy Space Queen (voiced by Pen Ward): commonly nicknamed as LSP, she’s generally portrayed as a spoiled teenage brat with a notorious need for attention and has much ignorance. She will insult anyone and everyone, with a snobbish air that seems to know no bounds, being best known for her insecurities which concern her appearance and her ability to turn another toon into a Lumpy Space person just by biting them.
- Mordecai (voiced by James G. Quintel): an anthropomorphic blue jay, famous for his laid back, mild mannered personality, pronounced vicenarian accent, depiction as a responsible slacker, and occupation as a groundskeeper.
- Rigby (voiced by William Salyers): Mordecai’s best friend. He’s commonly depicted as more free spirited than his subordinate, being his voice of sloth and a wild adult especially known by his immaturity.
- Megakranus Maellard (voiced by Samuel Marin): the chosen saviour of Lolliland. His main pleasure is to act in an ecstatic manner to anyone he meets, but he also has to bear the burden of being the park manager. He speaks in an unusually high pitched falsetto voice masked with a British accent. His catchphrase is "Good Show, jolly good show!".
- Benson Dunwoody (voiced by Dane Boedigheimer): a living gumball machine who utilises his inner rage and hatred for sloth to keep the park in line, rather than his job as assistant park manager, but partly fails everytime.
- Skips (voiced by Mark Hamill): a yeti who embodies much wisdom and plenty of immortality. He also bears knowledge of the distant past, having existed for such a long time.
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