- Jimmy Neutron as Mike
- Tommy Pickles (from Rugrats) as Young Mike
- Hugh Neutron as Derek Knight
- Butch Pakovski as Johnny Worthington
- Carl Wheezer as Sulley
- Chief Wiggum (from The Simpsons) as Brock Pearson
- Libby Folfax as Claire Wheeler
- Eustace Strych as Randall
- Sheen Estevez as Art
- Coach Gruber as Yeti
- Reptar (from Rugrats) and Ultra Lord as Terri Perry and Terry Perry
See also[]
- Monsters University/Jimmy Neutron