In Memory
Marlena
Patient Information
Age: 24
Sex: Female
Diagnosed: 1/05
Location: Virginia
Diagnosis: Stage III DSRCT
Hospital:
- Oncologist
No evidence of disease: 5/4/05
Relapse: 6/17/05
No evidence of disease: 1/17/06
Relapse: 12/13/06 - Lesions to the brain
Passed away: 7/27/07
Treatment
Surgery
- Debulking surgery with 90 minute heated chemo bath (Intraperitoneal hyperthermic chemoperfusion) done by Dr Paul Sugarbaker.
- Received a hysterectomy, splenectomy, greater omentectomy, a right colectomy, numerous lymph nodes in the abdomen were removed, gallbladder removed, diaphram was scraped, and tumor was removed from liver.
Chemotherapy
- First Line:
- Carboplatinum and Gemzar
- Daily Gleevec pills
- Second Line:
- Ifosfamide and Etoposide
- Vincristine, Doxorubicin, and Mesna
Stem Cell Rescue
- Fludarabine and Melphalan high dose chemo
- Allogeneic stem cell transplant. Received brothers stem cells.
- Granulocyte donor (white blood donor) - husband matches.
- Takes approximately 14 days for the new bone marrow to engraft
Radiation
- 18 different Fields (most people have only 2-4 Fields) and one treatment takes an hour. It stops 18 times for over 30 different “shots” of radiation that last about 15 seconds each. About 2/3 through the process have to be lined back up so they can do pelvic region. 4 weeks in the abdomen/pelvic area and 7 weeks on neck region (lympth nodes)
Relapse
- Cyber Knife
Time Line
| Date | Test | Treatment | Chemicals | Result |
|---|---|---|---|---|
| 1/5/05 | 0 | 0 | 0 | Diagnosed. CA-125 marker was 1030. (normal is 30) |
| 2/8/05 | 0 | Debulking surgery and intraperitoneal hyperthermic chemoperfusion. | 0 | 5 1/2 weeks in the hospital to recover from surgery. |
| 2/12/05 | 0 | Chemotherapy | Carboplatinum and Gemzar 1 | 0 |
| 3/05 | CT | 0 | 0 | Clear. |
| 3/05 | 0 | Chemotherapy | 0 | Once a week for three weeks with one week off. Daily Gleevac. |
| 4/05 | 0 | 0 | 0 | 0 |
| 5/4/05 | CT | 0 | 0 | Clear. No evidence of disease. |
| 5/25/05 | 0 | Chemotherapy Cycle 1 | 0 | 0 |
| 6/17/05 | Exam | 0 | 0 | Enlarged lymph nodes in the neck (measured 3.5cm). Relapse. |
| 6/05 | CT | 0 | 0 | "Shading" or marginal tumor growth in abdominal area, nothing solid. |
| 6/05 | 0 | Chemotherapy Cycle 2 | #1 Ifosfamide and Etoposide (given over 4 days) - #2 Vincristine, Doxorubicin, and Mesna (given in 1 day) | 0 |
| 7/05 | CT | Chemotherapy Cycle 3 | 0 | Lymph node in neck measures 1.6cm |
| 8/05 | 0 | Chemotherapy Cycle 4 | 0 | 0 |
| 9/17/05 | CT | Chemotherapy Cycle 5 | 0 | CT scan revealed significant shrinkage (1.3cm) - no more fluid around the lungs |
| 10/05 | 0 | Chemotherapy Cycle 6 | 0 | Shrinking. |
| 11/05 | 0 | Chemotherapy Cyle 7 | 0 | Dirty Harry still shrinking. :-) |
| 12/05 | 0 | Chemotherapy Cycle 8 | 0 | Dirty Harry gone. |
| 1/17/06 | CT | Chemotherapy Cycle 9 | 0 | CT scan clear except for 3cm cyst on bladder. No evidence of disease for all lympth nodes. |
| 2/06 | 0 | Chemotherapy Cycle 10 | 0 | 0 |
| 2/28/06 | MRI | 0 | 0 | No sign of tumor anywhere except the cyst on bladder and a nodule that may be dead tissue |
| 3/8/06 | PET | 0 | 0 | Fistula (small pocket of fluid) behind bladder -result from large surgery. The cyst did not light up, it's not cancer. Nodule gone. No evidence of disease. |
| 3/14/06 | 0 | Chemotherapy Cycle 11 | 0 | 0 |
| 4/6/06 | 0 | Chemotherapy Cycle 12 | 0 | 0 |
| 5/2/06 | 0 | Minor Surgery to place central line for Stem Cell transplant | 0 | 0 |
| 5/3/06 | 0 | High dose chemo to prepare for Stem Cell | Fludarabine. | Immune Globulin-Gamunex to boost immune system. |
| 5/05/06 | 0 | 0 | 0 | Admitted to Bone Marrow Transplant unit to start Stem Cell transplant |
| 5/7/06 | 0 | High dose chemotherapy | Melphelan | 0 |
| 5/9/06 | 0 | Allogeneic stem cell transplant started. Received brothers stem cells. | 0 | Husband providing granulocytes to boost white blood counts. |
| 6/3/06 | 0 | 0 | 0 | Stem Cells grafting. The ymphoyd cells (ones that kill cancer) are 100% brothers. Myelo cells (takes care of bacteria and fungus) are 75% brothers. |
| 6/7/06 | 0 | 0 | 0 | Released from hospital. |
| 6/15/06 | CT | 0 | 0 | Clean. No evidence of disease. |
| 6/30/06 | 0 | Radiation | 0 | 0 |
| 7/06 | 0 | Radiation | 0 | 0 |
| 8/06 | 0 | Radiation | 0 | 0 |
| 9/06 | 0 | 0 | 0 | 0 |
| 10/06 | 0 | 0 | 0 | 0 |
| 11/06 | 0 | 0 | 0 | 0 |
| 11/24/06 | Six months study from transplant | 0 | 0 | Everything okay |
| 12/1/06 | CT | 0 | 0 | Some abnormalities spotted on brain and liver |
| 12/11/06 | Biopsy on brain | 0 | 0 | 0 |
| 12/13/06 | 0 | 0 | Relapse | 2 large DSRCT lesions, several smaller lesions found on brain (9 in total) |
| 1/07 | 0 | CAM | 0 | 0 |
| 2/07 | 0 | CAM | 0 | 0 |
| 3/07 | CT | Consult about using 'cyber knife' | 0 | Slight growth in brain, 2 new lesions on liver |
| 4/07 | 0 | Gamma Knife used on 9 brain lesions. Chemotherapy. | 0 | Found a couple lesions on lungs. Chemo stopped for now. |
| 5/07 | 0 | 0 | 0 | 0 |
| 6/07 | 0 | 0 | 0 | 0 |
| 7/27/07 | 0 | 0 | 0 | Passed away |
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