Contents
First Line Chemotherapy
A. Original P6 = 7 cycles of high dose chemo:
- Cycle: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine with Mesna
- Cycle: Etoposide (VP-16); Ifosfamide
- 1. Modified by Dr Kushner
Adomanis, Jeff
- 2. Altered P6
- VACIME - Vincristine; Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Ifosfamide; Mesna; and Etoposide (VP-16), at very high doses.
Berman, Richard
- VACIME - Vincristine; Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Ifosfamide; Mesna; and Etoposide (VP-16), at very high doses.
- 3. Modified P6
Bishnow, Brian
- 4. P6 Variation - 6 cycles
- Cycle: Ifosfamide, Etoposide - 2 cycles
- Cycle: Vincristine, Doxorubicin, Cyclophosphamide - 4 cycles
Oberholzer, Chris
- 5. Variation of P6 - More sessions and lower than recommended dosage
- 4 Cycles: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine
- 3 Cycles: Etoposide (VP-16), Ifosfomide
Smith, Pamela
B. Kushner's DSRCT P6 Variation (Pediatric) = 6 cycles of high dose chemo
- Cycle 1,2,3,6 = Adriamycin (Doxorubicin);Cytoxan (Cyclophosphamide); Vincristine
- Cycle 4, 5= Cytoxan(Cyclophosphamide) and Topotecan
- 1. Variation of Kushner's P6 = 7 cycles
- Cycle 1, 5, 6, 7: Adriamycin (Doxorubicin);Cytoxan (Cyclophosphamide); Vincristine
- Cycle 2: Etoposide (VP-16) and Ifosfamide (Ifex)
- Cycle 3, 4: Cytoxan (Cyclophosphamide) and Topotecan
- 2. Variation of Kushner's P6
- Cyle 1,2,3 : Adriamycin (Doxorubicin); Ifosfamide, and Vincristine
- Cycle 4,5,6,9: Etoposide(VP-16); Ifosfamide
- Cycle 7,8 : Cytoxan(Cyclophosphamide) and Topotecan
Budimir-Hussey, Jordan
- 3. Variation of Kushner's P6
- Cycle 1, 2, 3, 4, 5: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide) and Vincristine
- Cycle 6, 7, 8, 9: Etoposide(VP-16); Ifosfamide
- Cycle 10, 11 Topotecan everyday for 2 weeks
Carfi, Christopher
- 4. Variation of Kushner's P6
- Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine; Topotecan, with Mesna
Shield, Jasmine
- Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine; Topotecan, with Mesna
C. P6 'Adult' Variation = based on Original P6 but with a longer time frame (10-14 cycles) and lower doses and sometimes without the Etoposide (VP-16) and Ifosomide.
Orantes, Meliza
D. Ewings Protocol (based on same 5 drugs as Original P6 but with a different time frame of 8 or more cycles and lower dosage of Cytoxan(Cyclophosphamide) and Ifosomide).
First Line Other Chemo Combinations
1. Adriamycin (Doxorubicin); Cisplatin; Etoposide(VP-16); Ifosfamide; and Vincristine
Abram, Jerry
2. Adriamycin (Doxorubicin); Cisplatin, Paclitaxel, Ifosfamide with Mesna
Corry, Nicola
3. Cycle: Adriamycin (Doxorubicin); Cisplatin; Vincristine
- Cycle: ICE = Ifosmoside; Carboplatin; Etoposide
Hickie, Dustin
4. Cycle: Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Cisplatin
- Cycle: ICE = Ifosmoside; Carboplatin; Etoposide
Denault, David
5. Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Etoposide(VP-16); Ifosfamide;
6. Adriamycin(Doxorubicin); Cytoxan(Cyclophosphamide); and Vincristine
7. Cycle: Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Vincristine
- Cycle: Cisplatin; Etoposide; Ifosfomide
Gibson, Sarah Taylor
8. Cyle: Adriamycin (Doxorubicin); Etoposide(VP-16); Ifosfamide, and Vincristine (VIDE - 6 rounds)
- Cycle: Vincristine, Ifosfamide, Etoposide (VIE - 7 rounds)
- Cycle: Etoposide and Cytoxan (Cyclophosphamide) - (1 round)
Broude, Robert
9. Cyle: Adriamycin (Doxorubicin); Etoposide(VP-16); Ifosfamide, and Vincristine (VIDE - 6 rounds)
Middelman, Erik
10. Adriamycin (Doxorubicin); Ifosfamide (Ifex)
Scranton, Patrick
11. Adriamycin(Doxorubicin); Ifosfamide(Ifex); and Vincristine
12. Adriblastin (Doxorubicin) (4 days); Ifosfamide(Ifex) (3 days), Platinol (Cisplatin) (1 day) - 4 day cycles
Schlegel, Maria
13. Asparaginase; Dactinomycin (Actinomycin D); Hydroxyurea
Martinson, Chad
14. Bleomycin; Etoposide(VP-16); Cisplatinum
15. Carboplatin; Dactiamycin; Epirubicin; Etoposid; Ifosfamide(Ifex); and Vincristine
Kiyici , Michael
16. Carboplatinum and Gemzar
Hodges, Marlena
17. Cisplatin; Decadron; Epirubicin; Etoposide(VP-16); Ifosfamide(Ifex); D545 with Mesna Vincristine;
Zucca , David
18. Docetaxel (Taxotere) and Gemcitabine (Gemzar)
Parrish, Joshua
19. Cycle: Epirubicin, Ifosfamide(Ifex) with Mesna, Vincristine
- Cycle: Cisplatinum; Etoposide
Mouktaroudes, Christos
20. Adriamycin (Doxorubicin); Imatinib mesylate (Gleevac), Vinblastin
Ramsey, Zach
F. Other First Line Drugs
1. Carboplatin
Martinson, Chad
2. Vinblastin
Second Line Chemotherapy
A. Cycles: Adriamycin (Doxorubicin, Doxil); Cytoxan(Cyclophosphamide); Vincristine
- Cycles: Etoposide (VP-16); Ifosfamide (Ifex)
Schafer, Ryan
B. Adriamycin (Doxorubicin, Doxil) and Ifosfamide (Ifex)
Bender , Michael
Wilson, Derek
C. Carboplatin; Cytoxan(Cyclophosphamide); Etoposide(VP-16) - 4 Cycles
Schafer, Ryan
D. Carboplatin and Paclitaxel (Taxol)
Denault, David
E. Cisplatin; Paclitaxel (Taxol)
Smith, Pamela
F. Cytoxan(Cyclophosphamide); Etoposide (VP-16); (High dose for stem cell transplant)
Gibson, Sarah Taylor
G. Cytoxan(Cyclophosphamide) and Topotecan (Hycamtin)
Hickie, Dustin
H. Imatinib mesylate (Gleevec) and Temozolomide (Temodar)
Carfi, Christopher
I. ICE = Ifosfamide (Ifex), Carboplatin, Etoposide (VP-16)
J. Irinotecan(Camptosar)and Temodar (Temozolimide)
K. Irinotecan (Camptosar) and oral Xeloda
Carfi, Christopher
L. VICE = Vincristine, Ifosfamide (Ifex), Cisplatin, and Etoposide(VP-16)
Sellers, Adam
M. VIP-E - Etoposide (VP-16), Ifosfamide, Cisplatin, and Epirubicin
- Falkenstein , Thomas
N. Sorafenib tosylate (Nexavar)
Braswell, Chris
Third Line and Other Chemo Combinations
A. Adriamycin (Doxorubicin), Cyclophosphamide (Cytoxin), Vincristine (higher dosage).
Carfi, Christopher
B. Adriamycin (Doxorubicin)(Doxil) and Thalidomide
Daunoras, Jay
C.Alimta and Cisplatnum
D. Cycle: Bleomycin; Cisplatin; Methotrexate; Vincristine
- Cycle: Actinomycin D; Cytoxan (Cyclophosphamide); Vincristine
Schafer, Ryan
E. Bexarotene (Targretin) and ICE protocol : Ifosfamide, Carboplatin, Etoposide
Daunoras, Jay
F. Bexarotene (Targretin) and ICE protocol , Thalidomide
Daunoras, Jay
G. CCT High-dose chemotherapy
- Cyclophosphamide (Cytoxan) 1500 mg/m2
- Carboplatin 200 mg/m2
- Thiotepa 125 mg/m2
- Falkenstein , Thomas
H. Carboplatin and Thiotepa (high dose chemotherapy for stem cell)
I. Cycle: Carboplatin and Paclitaxel (Taxol)
- Cycle: Adriamycin
Denault, David
J. Carboplatin; Thiotepa; Topotecan; - Stem Cell rescue
Shield, Jasmine
K. Casodex (hormonal therapy drug)and Thalidomide
Carfi, Christopher
L. Celebrex, oral Cyclophosphamide (Cytoxin), oral Etoposide (VP-16), Thalidomide ,
Carfi, Christopher
M.Cisplatnum and Etoposide (VP-16)
Cloer, Rebecca
N. Cisplatin and Irinotecan (Camptosar)
Martinson, Chad
O.Cyclophosphamide (Cytoxan) and Topotecan
Robertson,Nathan
P. Cyclophosphamide (Cytoxan); Thiotepa
Martinson, Chad
Q. Dactinomycin (Actinomycin), Ifosfamide (Ifex), Vincristine
Carfi, Christopher
R.Docetaxel (Taxotere) and Gemcitabine (Gemzar)
Cloer, Rebecca
S. Etoposide (Oral VP16), Thalidomide, Lupron
Daunoras, Jay
T. Methotrexate with Leucovorin
Martinson, Chad
Single Chemotherapies
1. Actinomycin(Dactinomycin)
2. Adriamycin (Doxorubicin)(Doxil)
Daunoras, Jay
3. Alimta
4. Bexarotene (Targretin)
Daunoras, Jay
5. Casodex (Bicalutamide) - hormonal therapy used in prostrate cancer.
6. Capecitabine
7. Celebrex (Celecoxib)
8. Cytoxan (Cyclophosphamide)
Denault, David
9. Decitabine
10. Doxil - (doxorubicin HCl liposome injection}
11. Etoposide (Oral VP16)
Daunoras, Jay
12. Gleevec - see Targeted therapies
14. Altretamine (Hexalen)
Smith, Pamela
15. Irinotecan
Cloer, Rebecca
Bishnow, Brian
Wilson, Derek
16. Lupron
17. Sirolimus (Rapamycin)
Daunoras, Jay
18. Thiotepa
Denault, David
19. Thalidomide
20. Topetecan
Sellers, Adam
21. Velcade (Bortezomib)
Martinson, Chad
22. Vinblastine (Velban)
Bodjanac, Nicole
Targeted Therapies
1. Imatinib mesylate also called Gleevec and STI-571
Schaut, Nikki
Wilson, Derek
Liles, Nikole
2. Sorafenib also called Nexavar
3. Sunitinib also called Sutent and SU11248
Clinical Trials
DSRCT References
Contact: dsrct.wiki@gmail.com
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