First Line Chemotherapy

A. Original P6 = 7 cycles of high dose chemo:

Cycle: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine with Mesna
Cycle: Etoposide (VP-16); Ifosfamide
Tinysunfl.jpgBender, Michael
Tinysunfl.jpgBidleman, Shawn
Tinysunfl.jpgDaunoras, Jay
Tinysunfl.jpgDeWalle, Mark
Tinysunfl.jpgHendricks, Haley
Tinysunfl.jpgHobbs , Caleb
Tinysunfl.jpgJenkins , Craig
Tinysunfl.jpgLunchuck, Timothy
Tinysunfl.jpgMays, Timothy
Tinysunfl.jpgSchaut , Nikki
Tinysunfl.jpgSellers, Adam
Tinysunfl.jpgSpithakis , Anthony
Tinysunfl.jpgVoss, Ken
Tinysunfl.jpgWebber, Gerry
1. Modified by Dr Kushner
Tinysunfl.jpgAdomanis, Jeff
2. Altered P6
VACIME - Vincristine; Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Ifosfamide; Mesna; and Etoposide (VP-16), at very high doses.
Tinysunfl.jpgBerman, Richard
3. Modified P6
Tinysunfl.jpgBishnow, Brian
4. P6 Variation - 6 cycles
Cycle: Ifosfamide, Etoposide - 2 cycles
Cycle: Vincristine, Doxorubicin, Cyclophosphamide - 4 cycles
Tinysunfl.jpgOberholzer, Chris
5. Variation of P6 - More sessions and lower than recommended dosage
4 Cycles: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine
3 Cycles: Etoposide (VP-16), Ifosfomide
Tinysunfl.jpgSmith, Pamela

B. Kushner's DSRCT P6 Variation (Pediatric) = 6 cycles of high dose chemo

Cycle 1,2,3,6 = Adriamycin (Doxorubicin);Cytoxan (Cyclophosphamide); Vincristine
Cycle 4, 5= Cytoxan(Cyclophosphamide) and Topotecan
Tinysunfl.jpgBrill, Steven
Tinysunfl.jpgLuder , Kristen
Tinysunfl.jpgPusey, Jade
Tinysunfl.jpgReichle, Brian
Tinysunfl.jpgWilson, Derek
1. Variation of Kushner's P6 = 7 cycles
Cycle 1, 5, 6, 7: Adriamycin (Doxorubicin);Cytoxan (Cyclophosphamide); Vincristine
Cycle 2: Etoposide (VP-16) and Ifosfamide (Ifex)
Cycle 3, 4: Cytoxan (Cyclophosphamide) and Topotecan
Tinysunfl.jpgWilson, Derek
2. Variation of Kushner's P6
Cyle 1,2,3 : Adriamycin (Doxorubicin); Ifosfamide, and Vincristine
Cycle 4,5,6,9: Etoposide(VP-16); Ifosfamide
Cycle 7,8 : Cytoxan(Cyclophosphamide) and Topotecan
Tinysunfl.jpgBudimir-Hussey, Jordan
3. Variation of Kushner's P6
Cycle 1, 2, 3, 4, 5: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide) and Vincristine
Cycle 6, 7, 8, 9: Etoposide(VP-16); Ifosfamide
Cycle 10, 11 Topotecan everyday for 2 weeks
Tinysunfl.jpgCarfi, Christopher
4. Variation of Kushner's P6
Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine; Topotecan, with Mesna
Tinysunfl.jpgShield, Jasmine


C. P6 'Adult' Variation = based on Original P6 but with a longer time frame (10-14 cycles) and lower doses and sometimes without the Etoposide (VP-16) and Ifosomide.

Tinysunfl.jpgOrantes, Meliza


D. Ewings Protocol (based on same 5 drugs as Original P6 but with a different time frame of 8 or more cycles and lower dosage of Cytoxan(Cyclophosphamide) and Ifosomide).

Tinysunfl.jpgRobertson , Nathan

First Line Other Chemo Combinations

1. Adriamycin (Doxorubicin); Cisplatin; Etoposide(VP-16); Ifosfamide; and Vincristine

Tinysunfl.jpgAbram, Jerry

2. Adriamycin (Doxorubicin); Cisplatin, Paclitaxel, Ifosfamide with Mesna

Tinysunfl.jpgCorry, Nicola

3. Cycle: Adriamycin (Doxorubicin); Cisplatin; Vincristine

Cycle: ICE = Ifosmoside; Carboplatin; Etoposide
Tinysunfl.jpgHickie, Dustin

4. Cycle: Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Cisplatin

Cycle: ICE = Ifosmoside; Carboplatin; Etoposide
Tinysunfl.jpgDenault, David

5. Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Etoposide(VP-16); Ifosfamide;

Tinysunfl.jpgWilson, Michael

6. Adriamycin(Doxorubicin); Cytoxan(Cyclophosphamide); and Vincristine

Tinysunfl.jpgMurray , Sheila
Tinysunfl.jpgLiles, Nikole

7. Cycle: Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Vincristine

Cycle: Cisplatin; Etoposide; Ifosfomide
Tinysunfl.jpgGibson, Sarah Taylor

8. Cyle: Adriamycin (Doxorubicin); Etoposide(VP-16); Ifosfamide, and Vincristine (VIDE - 6 rounds)

Cycle: Vincristine, Ifosfamide, Etoposide (VIE - 7 rounds)
Cycle: Etoposide and Cytoxan (Cyclophosphamide) - (1 round)
Tinysunfl.jpgBroude, Robert

9. Cyle: Adriamycin (Doxorubicin); Etoposide(VP-16); Ifosfamide, and Vincristine (VIDE - 6 rounds)

Tinysunfl.jpgMiddelman, Erik

10. Adriamycin (Doxorubicin); Ifosfamide (Ifex)

Tinysunfl.jpgScranton, Patrick

11. Adriamycin(Doxorubicin); Ifosfamide(Ifex); and Vincristine

Tinysunfl.jpgCloer, Rebecca
Tinysunfl.jpgBraswell , Chris

12. Adriblastin (Doxorubicin) (4 days); Ifosfamide(Ifex) (3 days), Platinol (Cisplatin) (1 day) - 4 day cycles

Tinysunfl.jpgSchlegel, Maria

13. Asparaginase; Dactinomycin (Actinomycin D); Hydroxyurea

Tinysunfl.jpgMartinson, Chad

14. Bleomycin; Etoposide(VP-16); Cisplatinum

Tinysunfl.jpgBerman, Richard
Tinysunfl.jpgStanley, Dave

15. Carboplatin; Dactiamycin; Epirubicin; Etoposid; Ifosfamide(Ifex); and Vincristine

Tinysunfl.jpgKiyici , Michael

16. Carboplatinum and Gemzar

Tinysunfl.jpgHodges, Marlena

17. Cisplatin; Decadron; Epirubicin; Etoposide(VP-16); Ifosfamide(Ifex); D545 with Mesna Vincristine;

Tinysunfl.jpgZucca , David

18. Docetaxel (Taxotere) and Gemcitabine (Gemzar)

Tinysunfl.jpgParrish, Joshua

19. Cycle: Epirubicin, Ifosfamide(Ifex) with Mesna, Vincristine

Cycle: Cisplatinum; Etoposide
Tinysunfl.jpgMouktaroudes, Christos

20. Adriamycin (Doxorubicin); Imatinib mesylate (Gleevac), Vinblastin

Tinysunfl.jpgRamsey, Zach

F. Other First Line Drugs

1. Carboplatin

Tinysunfl.jpgMartinson, Chad


2. Vinblastin

Second Line Chemotherapy

A. Cycles: Adriamycin (Doxorubicin, Doxil); Cytoxan(Cyclophosphamide); Vincristine

Cycles: Etoposide (VP-16); Ifosfamide (Ifex)
Tinysunfl.jpgSchafer, Ryan

B. Adriamycin (Doxorubicin, Doxil) and Ifosfamide (Ifex)

Tinysunfl.jpgBender , Michael
Tinysunfl.jpgWilson, Derek

C. Carboplatin; Cytoxan(Cyclophosphamide); Etoposide(VP-16) - 4 Cycles

Tinysunfl.jpgSchafer, Ryan

D. Carboplatin and Paclitaxel (Taxol)

Tinysunfl.jpgDenault, David

E. Cisplatin; Paclitaxel (Taxol)

Tinysunfl.jpgSmith, Pamela

F. Cytoxan(Cyclophosphamide); Etoposide (VP-16); (High dose for stem cell transplant)

Tinysunfl.jpgGibson, Sarah Taylor

G. Cytoxan(Cyclophosphamide) and Topotecan (Hycamtin)

Tinysunfl.jpgHickie, Dustin

H. Imatinib mesylate (Gleevec) and Temozolomide (Temodar)

Tinysunfl.jpgCarfi, Christopher

I. ICE = Ifosfamide (Ifex), Carboplatin, Etoposide (VP-16)

Tinysunfl.jpgCarfi, Christopher
Tinysunfl.jpgDenault, David

J. Irinotecan(Camptosar)and Temodar (Temozolimide)

Tinysunfl.jpgRobertson, Nathan
Tinysunfl.jpgJenkins , Craig
Tinysunfl.jpgPusey, Jade
Tinysunfl.jpgBodjanac, Nicole

K. Irinotecan (Camptosar) and oral Xeloda

Tinysunfl.jpgCarfi, Christopher

L. Sutent (Sunitinib malate)

Tinysunfl.jpgRicardo F
Tinysunfl.jpgDeWalle, Mark
Tinysunfl.jpgHahn, Tim
Tinysunfl.jpgSkurat, Steven

L. VICE = Vincristine, Ifosfamide (Ifex), Cisplatin, and Etoposide(VP-16)

Tinysunfl.jpgSellers, Adam

M. VIP-E - Etoposide (VP-16), Ifosfamide, Cisplatin, and Epirubicin

N. Sorafenib tosylate (Nexavar)

Tinysunfl.jpgBraswell, Chris

Third Line and Other Chemo Combinations

A. Adriamycin (Doxorubicin), Cyclophosphamide (Cytoxin), Vincristine (higher dosage).

Tinysunfl.jpgCarfi, Christopher

B. Adriamycin (Doxorubicin)(Doxil) and Thalidomide

Tinysunfl.jpgDaunoras, Jay

C.Alimta and Cisplatnum

Tinysunfl.jpgOtt, Keegan

D. Cycle: Bleomycin; Cisplatin; Methotrexate; Vincristine

Cycle: Actinomycin D; Cytoxan (Cyclophosphamide); Vincristine
Tinysunfl.jpgSchafer, Ryan

E. Bexarotene (Targretin) and ICE protocol : Ifosfamide, Carboplatin, Etoposide

Tinysunfl.jpgDaunoras, Jay

F. Bexarotene (Targretin) and ICE protocol , Thalidomide

Tinysunfl.jpgDaunoras, Jay

G. CCT High-dose chemotherapy

Cyclophosphamide (Cytoxan) 1500 mg/m2
Carboplatin 200 mg/m2
Thiotepa 125 mg/m2

H. Carboplatin and Thiotepa (high dose chemotherapy for stem cell)

Tinysunfl.jpgDaunoras, Jay
Tinysunfl.jpgLunchuck, Timothy

I. Cycle: Carboplatin and Paclitaxel (Taxol)

Cycle: Adriamycin
Tinysunfl.jpgDenault, David

J. Carboplatin; Thiotepa; Topotecan; - Stem Cell rescue

Tinysunfl.jpgShield, Jasmine


K. Casodex (hormonal therapy drug)and Thalidomide

Tinysunfl.jpgCarfi, Christopher

L. Celebrex, oral Cyclophosphamide (Cytoxin), oral Etoposide (VP-16), Thalidomide ,

Tinysunfl.jpgCarfi, Christopher

M.Cisplatnum and Etoposide (VP-16)

Tinysunfl.jpgCloer, Rebecca

N. Cisplatin and Irinotecan (Camptosar)

Tinysunfl.jpgMartinson, Chad

O.Cyclophosphamide (Cytoxan) and Topotecan

Tinysunfl.jpgRobertson,Nathan

P. Cyclophosphamide (Cytoxan); Thiotepa

Tinysunfl.jpgMartinson, Chad

Q. Dactinomycin (Actinomycin), Ifosfamide (Ifex), Vincristine

Tinysunfl.jpgCarfi, Christopher

R.Docetaxel (Taxotere) and Gemcitabine (Gemzar)

Tinysunfl.jpgCloer, Rebecca

S. Etoposide (Oral VP16), Thalidomide, Lupron

Tinysunfl.jpgDaunoras, Jay

T. Methotrexate with Leucovorin

Tinysunfl.jpgMartinson, Chad

Single Chemotherapies

1. Actinomycin(Dactinomycin)

2. Adriamycin (Doxorubicin)(Doxil)

Tinysunfl.jpgDaunoras, Jay

3. Alimta

4. Bexarotene (Targretin)

Tinysunfl.jpgDaunoras, Jay

5. Casodex (Bicalutamide) - hormonal therapy used in prostrate cancer.

6. Capecitabine

7. Celebrex (Celecoxib)

8. Cytoxan (Cyclophosphamide)

Tinysunfl.jpgDenault, David

9. Decitabine

Tinysunfl.jpgWilson, Derek

10. Doxil - (doxorubicin HCl liposome injection}

11. Etoposide (Oral VP16)

Tinysunfl.jpgDaunoras, Jay

12. Gleevec - see Targeted therapies


13. Gemcitabine ( Gemzar )

Tinysunfl.jpgBishnow, Brian
Tinysunfl.jpgDaunoras, Jay
Tinysunfl.jpgMartinson, Chad
Tinysunfl.jpgScranton, Patrick

14. Altretamine (Hexalen)

Tinysunfl.jpgSmith, Pamela


15. Irinotecan

Tinysunfl.jpgCloer, Rebecca
Tinysunfl.jpgBishnow, Brian
Tinysunfl.jpgWilson, Derek

16. Lupron

Tinysunfl.jpgCarfi, Christopher
Tinysunfl.jpgDaunoras, Jay

17. Sirolimus (Rapamycin)

Tinysunfl.jpgDaunoras, Jay

18. Thiotepa

Tinysunfl.jpgDenault, David

19. Thalidomide

Tinysunfl.jpgWilson, Derek

20. Topetecan

Tinysunfl.jpgSellers, Adam

21. Velcade (Bortezomib)

Tinysunfl.jpgMartinson, Chad

22. Vinblastine (Velban)

Tinysunfl.jpgBodjanac, Nicole

Targeted Therapies

1. Imatinib mesylate also called Gleevec and STI-571

Tinysunfl.jpgSchaut, Nikki
Tinysunfl.jpgWilson, Derek
Tinysunfl.jpgLiles, Nikole

2. Sorafenib also called Nexavar

Tinysunfl.jpgBraswell, Christian
Tinysunfl.jpgByrd, David

3. Sunitinib also called Sutent and SU11248

Tinysunfl.jpgDeWalle, Mark
Tinysunfl.jpgHobbs, Caleb
Tinysunfl.jpgRobertson, Nathan
Tinysunfl.jpgSkurat, Steven

Clinical Trials

See Groups by Clinical Trial

DSRCT References

Contact: dsrct.wiki@gmail.com

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