Groups by Chemotherapy

First Line Chemotherapy

A. Original P6 = 7 cycles of high dose chemo:

Cycle: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine with Mesna

Cycle: Etoposide (VP-16); Ifosfamide

Bender, Michael

Bidleman, Shawn

Daunoras, Jay

DeWalle, Mark

Hendricks, Haley

Hobbs , Caleb

Jenkins , Craig

Lunchuck, Timothy

Mays, Timothy

Schaut , Nikki

Sellers, Adam

Spithakis , Anthony

Voss, Ken

Webber, Gerry

1. Modified by Dr Kushner

Adomanis, Jeff

2. Altered P6

VACIME - Vincristine; Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Ifosfamide; Mesna; and Etoposide (VP-16), at very high doses.

Berman, Richard

3. Modified P6

Bishnow, Brian

4. P6 Variation - 6 cycles

Cycle: Ifosfamide, Etoposide - 2 cycles

Cycle: Vincristine, Doxorubicin, Cyclophosphamide - 4 cycles

Oberholzer, Chris

5. Variation of P6 - More sessions and lower than recommended dosage

4 Cycles: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine

3 Cycles: Etoposide (VP-16), Ifosfomide

Smith, Pamela

B. Kushner's DSRCT P6 Variation (Pediatric) = 6 cycles of high dose chemo

Cycle 1,2,3,6 = Adriamycin (Doxorubicin);Cytoxan (Cyclophosphamide); Vincristine

Cycle 4, 5= Cytoxan(Cyclophosphamide) and Topotecan

Brill, Steven

Luder , Kristen

• Marquis , Jordan
• Orgel , Greg

Pusey, Jade

Reichle, Brian

Wilson, Derek

1. Variation of Kushner's P6 = 7 cycles

Cycle 1, 5, 6, 7: Adriamycin (Doxorubicin);Cytoxan (Cyclophosphamide); Vincristine

Cycle 2: Etoposide (VP-16) and Ifosfamide (Ifex)

Cycle 3, 4: Cytoxan (Cyclophosphamide) and Topotecan

Wilson, Derek

2. Variation of Kushner's P6

Cyle 1,2,3 : Adriamycin (Doxorubicin); Ifosfamide, and Vincristine

Cycle 4,5,6,9: Etoposide(VP-16); Ifosfamide

Cycle 7,8 : Cytoxan(Cyclophosphamide) and Topotecan

Budimir-Hussey, Jordan

3. Variation of Kushner's P6

Cycle 1, 2, 3, 4, 5: Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide) and Vincristine

Cycle 6, 7, 8, 9: Etoposide(VP-16); Ifosfamide

Cycle 10, 11 Topotecan everyday for 2 weeks

Carfi, Christopher

4. Variation of Kushner's P6

Adriamycin (Doxorubicin); Cytoxan (Cyclophosphamide); Vincristine; Topotecan, with Mesna

Shield, Jasmine

C. P6 'Adult' Variation = based on Original P6 but with a longer time frame (10-14 cycles) and lower doses and sometimes without the Etoposide (VP-16) and Ifosomide.

Orantes, Meliza

D. Ewings Protocol (based on same 5 drugs as Original P6 but with a different time frame of 8 or more cycles and lower dosage of Cytoxan(Cyclophosphamide) and Ifosomide).

• Spencer , Richard - Eicess EVAIA

Robertson , Nathan

First Line Other Chemo Combinations

1. Adriamycin (Doxorubicin); Cisplatin; Etoposide(VP-16); Ifosfamide; and Vincristine

Abram, Jerry

2. Adriamycin (Doxorubicin); Cisplatin, Paclitaxel, Ifosfamide with Mesna

Corry, Nicola

3. Cycle: Adriamycin (Doxorubicin); Cisplatin; Vincristine

Cycle: ICE = Ifosmoside; Carboplatin; Etoposide

Hickie, Dustin

4. Cycle: Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Cisplatin

Cycle: ICE = Ifosmoside; Carboplatin; Etoposide

Denault, David

5. Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Etoposide(VP-16); Ifosfamide;

Wilson, Michael

6. Adriamycin(Doxorubicin); Cytoxan(Cyclophosphamide); and Vincristine

Murray , Sheila

Liles, Nikole

7. Cycle: Adriamycin (Doxorubicin); Cytoxan(Cyclophosphamide); Vincristine

Cycle: Cisplatin; Etoposide; Ifosfomide

Gibson, Sarah Taylor

8. Cyle: Adriamycin (Doxorubicin); Etoposide(VP-16); Ifosfamide, and Vincristine (VIDE - 6 rounds)

Cycle: Vincristine, Ifosfamide, Etoposide (VIE - 7 rounds)

Cycle: Etoposide and Cytoxan (Cyclophosphamide) - (1 round)

Broude, Robert

9. Cyle: Adriamycin (Doxorubicin); Etoposide(VP-16); Ifosfamide, and Vincristine (VIDE - 6 rounds)

Middelman, Erik

10. Adriamycin (Doxorubicin); Ifosfamide (Ifex)

Scranton, Patrick

11. Adriamycin(Doxorubicin); Ifosfamide(Ifex); and Vincristine

Cloer, Rebecca

Braswell , Chris

12. Adriblastin (Doxorubicin) (4 days); Ifosfamide(Ifex) (3 days), Platinol (Cisplatin) (1 day) - 4 day cycles

Schlegel, Maria

13. Asparaginase; Dactinomycin (Actinomycin D); Hydroxyurea

Martinson, Chad

14. Bleomycin; Etoposide(VP-16); Cisplatinum

Berman, Richard

Stanley, Dave

15. Carboplatin; Dactiamycin; Epirubicin; Etoposid; Ifosfamide(Ifex); and Vincristine

Kiyici , Michael

16. Carboplatinum and Gemzar

Hodges, Marlena

17. Cisplatin; Decadron; Epirubicin; Etoposide(VP-16); Ifosfamide(Ifex); D545 with Mesna Vincristine;

Zucca , David

18. Docetaxel (Taxotere) and Gemcitabine (Gemzar)

Parrish, Joshua

19. Cycle: Epirubicin, Ifosfamide(Ifex) with Mesna, Vincristine

Cycle: Cisplatinum; Etoposide

Mouktaroudes, Christos

20. Adriamycin (Doxorubicin); Imatinib mesylate (Gleevac), Vinblastin

Ramsey, Zach

F. Other First Line Drugs

1. Carboplatin

Martinson, Chad

2. Vinblastin

Second Line Chemotherapy

A. Cycles: Adriamycin (Doxorubicin, Doxil); Cytoxan(Cyclophosphamide); Vincristine

Cycles: Etoposide (VP-16); Ifosfamide (Ifex)

Schafer, Ryan

B. Adriamycin (Doxorubicin, Doxil) and Ifosfamide (Ifex)

Bender , Michael

Wilson, Derek

C. Carboplatin; Cytoxan(Cyclophosphamide); Etoposide(VP-16) - 4 Cycles

Schafer, Ryan

D. Carboplatin and Paclitaxel (Taxol)

Denault, David

E. Cisplatin; Paclitaxel (Taxol)

Smith, Pamela

F. Cytoxan(Cyclophosphamide); Etoposide (VP-16); (High dose for stem cell transplant)

Gibson, Sarah Taylor

G. Cytoxan(Cyclophosphamide) and Topotecan (Hycamtin)

Hickie, Dustin

H. Imatinib mesylate (Gleevec) and Temozolomide (Temodar)

Carfi, Christopher

I. ICE = Ifosfamide (Ifex), Carboplatin, Etoposide (VP-16)

Carfi, Christopher

Denault, David

J. Irinotecan(Camptosar)and Temodar (Temozolimide)

Robertson, Nathan

Jenkins , Craig

Pusey, Jade

Bodjanac, Nicole

K. Irinotecan (Camptosar) and oral Xeloda

Carfi, Christopher

L. Sutent (Sunitinib malate)

Ricardo F

DeWalle, Mark

Hahn, Tim

Skurat, Steven

L. VICE = Vincristine, Ifosfamide (Ifex), Cisplatin, and Etoposide(VP-16)

Sellers, Adam

M. VIP-E - Etoposide (VP-16), Ifosfamide, Cisplatin, and Epirubicin

• Falkenstein , Thomas

N. Sorafenib tosylate (Nexavar)

Braswell, Chris

Third Line and Other Chemo Combinations

A. Adriamycin (Doxorubicin), Cyclophosphamide (Cytoxin), Vincristine (higher dosage).

Carfi, Christopher

B. Adriamycin (Doxorubicin)(Doxil) and Thalidomide

Daunoras, Jay

C.Alimta and Cisplatnum

Ott, Keegan

D. Cycle: Bleomycin; Cisplatin; Methotrexate; Vincristine

Cycle: Actinomycin D; Cytoxan (Cyclophosphamide); Vincristine

Schafer, Ryan

E. Bexarotene (Targretin) and ICE protocol : Ifosfamide, Carboplatin, Etoposide

Daunoras, Jay

F. Bexarotene (Targretin) and ICE protocol , Thalidomide

Daunoras, Jay

G. CCT High-dose chemotherapy

Cyclophosphamide (Cytoxan) 1500 mg/m2

Carboplatin 200 mg/m2

Thiotepa 125 mg/m2

• Falkenstein , Thomas

H. Carboplatin and Thiotepa (high dose chemotherapy for stem cell)

Daunoras, Jay

Lunchuck, Timothy

I. Cycle: Carboplatin and Paclitaxel (Taxol)

Cycle: Adriamycin

Denault, David

J. Carboplatin; Thiotepa; Topotecan; - Stem Cell rescue

Shield, Jasmine

K. Casodex (hormonal therapy drug)and Thalidomide

Carfi, Christopher

L. Celebrex, oral Cyclophosphamide (Cytoxin), oral Etoposide (VP-16), Thalidomide ,

Carfi, Christopher

M.Cisplatnum and Etoposide (VP-16)

Cloer, Rebecca

N. Cisplatin and Irinotecan (Camptosar)

Martinson, Chad

O.Cyclophosphamide (Cytoxan) and Topotecan

Robertson,Nathan

P. Cyclophosphamide (Cytoxan); Thiotepa

Martinson, Chad

Q. Dactinomycin (Actinomycin), Ifosfamide (Ifex), Vincristine

Carfi, Christopher

R.Docetaxel (Taxotere) and Gemcitabine (Gemzar)

Cloer, Rebecca

S. Etoposide (Oral VP16), Thalidomide, Lupron

Daunoras, Jay

T. Methotrexate with Leucovorin

Martinson, Chad

Single Chemotherapies

1. Actinomycin(Dactinomycin)

2. Adriamycin (Doxorubicin)(Doxil)

Daunoras, Jay

3. Alimta

4. Bexarotene (Targretin)

Daunoras, Jay

5. Casodex (Bicalutamide) - hormonal therapy used in prostrate cancer.

6. Capecitabine

7. Celebrex (Celecoxib)

8. Cytoxan (Cyclophosphamide)

Denault, David

9. Decitabine

Wilson, Derek

10. Doxil - (doxorubicin HCl liposome injection}

11. Etoposide (Oral VP16)

Daunoras, Jay

12. Gleevec - see Targeted therapies

13. Gemcitabine ( Gemzar )

Bishnow, Brian

Daunoras, Jay

Martinson, Chad

Scranton, Patrick

14. Altretamine (Hexalen)

Smith, Pamela

15. Irinotecan

Cloer, Rebecca

Bishnow, Brian

Wilson, Derek

16. Lupron

Carfi, Christopher

Daunoras, Jay

17. Sirolimus (Rapamycin)

Daunoras, Jay

18. Thiotepa

Denault, David

19. Thalidomide

Wilson, Derek

20. Topetecan

Sellers, Adam

21. Velcade (Bortezomib)

Martinson, Chad

22. Vinblastine (Velban)

Bodjanac, Nicole

Targeted Therapies

1. Imatinib mesylate also called Gleevec and STI-571

Schaut, Nikki

Wilson, Derek

Liles, Nikole

2. Sorafenib also called Nexavar

Braswell, Christian

Byrd, David

3. Sunitinib also called Sutent and SU11248

DeWalle, Mark

Hobbs, Caleb

Robertson, Nathan

Skurat, Steven

Clinical Trials

See Groups by Clinical Trial

DSRCT References

Contact: dsrct.wiki@gmail.com

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