Movie version[]
- Nazz as Tillie
- Marie Kanker as Georgia
- Ed/Double D as Doc
- The Red Guy (from Cow & Chicken) as Farnsworth
- Bossman (from The Powerpuff Girls) as Pete
- I M Weasel (from I M Weasel) as Jebediah
- Eddy as Chip
- Big Mickey (from TUGS) as Tower
- Big Billy (from The Powerpuff Girls) as Rollo The Clown
- Daisy (from Thomas and Friends) as Grumpella
- Hank (from Theodore Tugboat) as Chippers
- Johnny as Perky
- Kevin as Handy Pandy
- Rolf as Stretch
- Wendy Darling (from Peter Pan) as Missy
- Ed as Eric
- Belle (from Beauty and the Beast) as Jill
- Mojo Jojo (from The Powerpuff Girls) as The Big Wolf
- Sheep (from Sheep In The Big City) as The Little Wolf
- Kaa (from The Jungle Book) as The Eagle
- Eddy's Brother as The Voice Inside The Cave
Book version[]
- Eddy as the Clown
- Ed as The Litte Blue Engine
- Nazz as The Little Red Train
- Kevin as The Shiny New Engine
- Rolf as The Big Strong Engine