Discord Jones is Nephelodeon's movie spoof of Osmosis Jones.
- Osmosis Jones - Discord (MLP:FIM)
- Drix - Bumblebee (Transformers Animated)
- Leah Estrogen - Fluttershy (MLP:FIM)
- The Chief of Police - Starswirl the Bearded (MLP:FIM)
- Mayor Phlegmming - Lord Rataxes (Babar)
- Thrax - Bill Cipher (Gravity Falls)
- Bruiser - Sandman (The Spectacular Spider-Man)
- Tom Colonic - King Babar (Babar)
- Spider Legs - Beastly (The Care Bears Family)
- The Crime Boss - Tombstone (The Spectacular Spider-Man)
- The Flu Germ - Pikachu (Pokemon)
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