Cast[]
- Samurai Jack as Captain America (both are warriors from different timelines)
- Dexter (from Dexter's Laboratory) as Iron Man (they're both geniuses with lots of technology)
- Grim (from The Grim Adventures of Billy & Mandy) as Thor (both are powerful beings)
- Fourarms (from Ben 10) as the Hulk (Ben Tennyson as Bruce Banner)
- Numbuh 5 (from Codename: Kids Next Door) as Black Widow
- Numbuh 2 (from Codename: Kids Next Door) as Hawkeye
- The Scotsman (from Samurai Jack) as the Winter Soldier
- Generator Rex as the Falcon
- Cyborg (from Teen Titans) as War Machine
- Larry 3000 (from Time Squad) as Vision
- Prohyas Warrior (from Mighty Magiswords) as Quicksilver
- Vambre Warrior (from Mighty Magiswords) as Scarlet Witch
- Gumball Watterson (from the Amazing World of Gumball) as Ant-Man
- Penny Fitzgerald (from the Amazing World of Gumball) as The Wasp
- K.O. (from OK K.O.! Let's Be Heroes) as Spider-Man
- Blossom (from The Powerpuff Girls) as Captain Marvel
- Robin Snyder (from The Powerpuff Girls) as Ms. Marvel
- Human!Mondo (from Courage the Cowardly Dog) as Doctor Strange
- Shirley the Medium (from Courage the Cowardly Dog) as the Ancient One
- Numbuh 1 (from Codename: Kids Next Door) as Nick Fury
- Numbuh 101 (from Codename: Kids Next Door) as Phil Coulson
- Numbuh 362 (from Codename: Kids Next Door) as Maria Hill
- Little Suzy (from Johnny Bravo) as Pepper Potts
- Kai Green (from Ben 10) as Betty Ross
- The Red Guy (from Cow & Chicken) as Red Skull
- Mandark (from Dexter's Laboratory) as Iron Monger
- The Boogeyman (from The Grim Adventures of Billy & Mandy) as Loki
- Eris (from The Grim Adventures of Billy & Mandy) as Hela
- The aliens from the "Cartoon Network Invaded" event as the Chitauri
- Vilgax (from Ben 10) as the Leader
- Albedo (from Ben 10) as Abomination
- TOM (from Toonami) as Star-Lord (both are quippy intergalactic heroes)
- Sara (from Toonami) as Gamora
- Grizz (from We Bare Bears) as Drax the Destroyer
- Rigby (from Regular Show) as Rocket Raccoon (both are raccoons who mouth off a lot)
- Larry (from Teen Titans) as Groot
- Lapis Lazuli (from Steven Universe) as Mantis
- Peridot (from Steven Universe) as Nebula
- Craig Williams (from Craig of the Creek) as the Black Panther
- Mac (from Foster's Home for Imaginary Friends) as Cyclops
- Bloo (from Foster's Home for Imaginary Friends) as Nightcrawler
- Coco (from Foster's Home for Imaginary Friends) as Mystique
- Eduardo (from Foster's Home for Imaginary Friends) as Beast
- Wilt (from Foster's Home for Imaginary Friends) as Gambit
- Frankie (from Foster's Home for Imaginary Friends) as Phoenix
- Cheese (from Foster's Home for Imaginary Friends) as Iceman
- Mr. Herriman (from Foster's Home for Imaginary Friends) as Professor X
- Ed (from Ed, Edd 'n Eddy) as Deadpool
- Muriel (from Courage the Cowardly Dog) as Blind Al
- Kevin (from Ed, Edd 'n Eddy) as Cable
- Finn the Human (from Adventure Time) as Daredevil
- Marceline (from Adventure Time) as Elektra Natchios
- Tulip (from Infinity Train) as Jessica Jones
- Maurice (from Codename: Kids Next Door) as Luke Cage
- Mao Mao (from Mao Mao: Heroes of Pure Heart) as Iron Fist
- Hoss Delgado (from The Grim Adventures of Billy & Mandy) as the Punisher
- Chicken (from Cow & Chicken) as Howard the Duck
- Marcus Conner (from The Life and Times of Juniper Lee) as Mr. Fantastic
- Juniper Lee (from The Life and Times of Juniper Lee) as the Invisible Woman
- Ray Ray Lee (from The Life and Times of Juniper Lee) as the Human Torch
- Roger Radcliffe (from The Life and Times of Juniper Lee) as the Thing
- HIM (from The Powerpuff Girls) as Thanos
- Swayzak (from Toonami) as Doc.X
- Kim (from The Powerpuff Girls) as Kaylee Kirk
- Loki (from The Life and Times of Juniper Lee) as Doctor Doom
- The Narrator (from The Powerpuff Girls) as the One-Above-All
Trivia[]
- The Quinjets have been replaced with the KND S.C.A.M.P.E.R.s.
- The Tesseract has been replaced with the Left-Hand of Horror.
Voice actors[]
- Phil LaMarr as Samurai Jack, Wilt, and Marcus Conner
- Candi Milo as Dexter, Coco, and Cheese
- Greg Ayres as Grim
- Yuri Lowenthal as Ben Tennyson and Albedo
- Dee Bradley Baker as Fourarms and Larry
- Cree Summer as Numbuh 5
- Benjamin Diskin as Numbuh 2, Numbuh 1, and Numbuh 101
- John DiMaggio as The Scotsman
- Daryl Sabara as Generator Rex
- Khary Payton as Cyborg and Maurice
- Mark Hamill as Larry 3000
- Kyle Carrozza as Prohyas Warrior
- Grey Griffin as Vambre Warrior and Frankie
- Nicolas Cantu as Gumball Watterson
- Teresa Gallaghar as Penny Fitzgerald
- Courtenay Taylor as K.O.
- Cathy Cavadini as Blossom
- Julie Nathanson as Robin Snyder
- David O'Brien as Mondo
- Mary Testa as Shirley the Medium
- Rachel MacFarlane as Numbuh 362 and Eris
- Mae Whitman as Little Suzy
- Bettina Bush as Kai Green
- Charlie Adler as The Red Guy and Chicken
- Eddie Deezen as Mandark
- Fred Willard as The Boogeyman
- Steven Blum as Vilgax and TOM
- Samantha Robson as Sara
- Eric Edelstein as Grizz
- William Salyers as Rigby
- Jennifer Paz as Lapis Lazuli
- Shelby Rabara as Peridot
- Phillip Solomon as Craig Williams
- Sean Marquette as Mac
- Keith Ferguson as Bloo
- Tom Kenny as Eduardo and the Narrator
- Tom Kane as Mr. Herriman and HIM
- Matt Hill as Ed
- Kathleen Barr as Kevin
- Tress MacNeille as Muriel
- Jeremy Shada as Finn the Human
- Olivia Olson as Marceline
- Ashley Johnson as Tulip
- Parker Simmons as Mao Mao
- Diedrich Bader as Hoss Delgado
- Lara Jill Miller as Juniper Lee
- Kath Soucie as Ray Ray Lee
- Tara Strong as Roger Radcliffe
- Bob Amaral as Swayzak
- Jennifer Hale as Kim
- Jeff Bennett as Loki