Cast:[]
- Flavio as Manny
- Yakko Warner as Sid
- Wakko Warner as Diego
- Skippy Squirrel as Scrat
- Charlton Woodchucks as Roshan
- Marita as Ellie
- Pinky and The Brain as Crash & Eddie
- Stephen Wolf as Lone Gunslinger
- Bobby as Fast Tony
- Schnitzel and Floyd as Cretaceous and Maelstrom
- Mindy as Scratte
- Dr. Otto Scratchansniff as Buck
- Rita as Peaches
- Walter Wolf as Soto
- Captain Mel as Zeke
- Sid the Squid as Lenny
- Beanie the Brain-Dead Bison as Oscar
- Caw-Caw and Charlie as Carl and Frank
- The Survey Ladies as Jennifer and Rachel
- Chicken Boo as Dab
- Wilford Wolf as Stu
- Pip as Cholly
- Colin as Gazelle
- Hello Nurse as Shira
- King Salazar as Captain Gutt
- The Snake as Silas
- Miss Flamiel as Raz
- Stinkbomb as Flynn
- Bumpo as Squint
- Doug The Dog as Dobson
- Newt as Gupta
- Dot Warner as Sid's Grandmother
- Ralph as Ethan
- Ralph's Wife as Steffie
- Neivel Nosenest as Ethan's Buddy
- Sasha as Katie
- Katie Ka-Boom as Meghan
- Duke as Rudy
- Pipsqueak as Louis
- Buttons as Marshall
- Baloney as Milton
- Runt as Uncle Fungus
- Suzy Squirrel as Eunice
- Solley the Godpigeon as Ariscratle
- The Clown as Clint
- Mr. Plotz as Julian
- Minerva Mink as Brooke
- The Mime as Shangri Llama
- Pesto as Gavin
- Slappy Squirrel as Gertie
- Squit as Roger
- Kiki and Lana as Bubbles and Misty
- Mr. Skullhead as Teddy
- Sheila Squirrel as Francine
- Mr. Director as Neil deBuck Weasel