Clinical Trials

Introduction
This section will provide links to various Clinical Trials that may be of interest to patients with desmoplastic small round cell tumors. Please check the links, the dates of the trial, eligibility, and contact information thoroughly.

As with any treatment for DSRCT some of these drugs may work for certain patients depending upon body type, age, health circumstances, disease stage, and probably just luck.

Locations for the clinical trials may be varied or may be localized, please check with your physician or call directly. You may be able to find a clinical trial closer to where you live. Ask.

Clinical Trials may be conducted by government health agencies such as NIH, researchers affiliated with a hospital or university medical program, independent researchers, or private industry.

Please remember that in Clinical Trials, especially Phase 1 trials that you may not be receiving the best dosage of drug (you may even receive a placebo) to treat your disease. Clinical Trials should be undertaken at the advice and guidance of a qualified oncologist who is interested in your specific well being. The Trial may not be effective for your needs. Consider also that Clinical Trials will take up valuable time.

Phase 1 Clinical Trials - First study that determines how the drugs will affect human beings, the side effects associated with increasing doses, and to begin the process of evaluating the drugs effectiveness; may include healthy participants and/or patients. Phase 1 trials generally can include a large group of people. Phase 1 trials are investigational and patients should remember that they may be in a cohort that does not receive the full benefit of the drugs or treatments.
 * Important Definitions:

Phase II

Phase 1 Clinical Trials
1. 17-N-Allylamino-17-Demethoxygeldanamycin (17-AAG) in Treating Young Patients With Recurrent or Refractory Leukemia or Solid Tumors -No longer recruiting patients

2. Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer -This study is currently recruiting patients. Verified by National Cancer Institute (NCI) April 2007

3. Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer - This study is currently recruiting patients. Verified by National Cancer Institute (NCI) May 2007

4. Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Abdominal Cancer - This study is currently recruiting patients. Verified by M.D. Anderson Cancer Center February 2007

5. Drug Interaction Study of Sorafenib and Rapamycin in Advanced Malignacies - This study is currently recruiting patients. Verified by University of Chicago March 2007

6. Study of ZIO-201 in Advanced Sarcoma - Phase 1/Phase 2. The study of safety of Isophosphoramide Mustard (IPM) in the treatment of advanced sarcoma. A Phase IB/IIA Study of the Saftey and Activity of Intravenous Isophosporamide Mustard (ZIO-201) in Patients With Advanced Sarcoma This study is currently recruiting patients. Verified by ZIOPHARM February 2007

7. CCI-779 and EKB-569 in Treating Patients With Advanced Solid Tumors - This study is currently recruiting patients. Verified by National Cancer Institute (NCI) May 2007 CCI-779 (Temsirolimus)

8. One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy - This study is currently recruiting patients. Verified by Sidney Kimmel Comprehensive Cancer Center April 2007

9. Safety Study of IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) or Soft Tissue Sarcomas (STS) - (HSP90)IPI-504 is a novel, water-soluble analog of 17-AAG and a potent inhibitor of Hsp90. This study is currently recruiting patients. Verified by Infinity Pharmaceuticals May 2007

Phase II Clinical Trials
1. Phase II Trial of Imatinib Mesylate (Gleevec) in Therapy of Ewing's Family of Tumors and Desmoplastic Small Round Cell Tumors No longer recruiting

2. Phase II Study of AP23573, An MTOR Inhibitor, in Patients with Advanced Sarcoma - No longer recruiting

3. Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors - This study has been suspended. Verified by National Cancer Institute (NCI) April 2007

4. Chemotherapy Followed by Donor Peripheral Stem Cell Transplantation in Treating Young Patients With Recurrent Sarcoma - This study is currently recruiting patients. Verified by National Cancer Institute (NCI) February 2007 ary.

5. Mitomycin as a Hyperthermic Peritoneal Perfusion in Treating Patients With Malignant Ascites - This study is no longer recruiting patients.

6. FR901228 (Depsipeptide)  in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma This study is currently recruiting patients. Verified by National Cancer Institute (NCI) March 2007

7. Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors This study has been suspended. Verified by National Cancer Institute (NCI) June 2007

8. Ecteinascidin 743 in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors - [Yondelis] This study is not yet open for patient recruitment. Verified by National Cancer Institute (NCI) May 2007

9. a Multicenter Clinical Trial for the Treatment of Children and Adolescents With Soft Tissue Sarcoma Stage 4 This study is currently recruiting patients. Verified by Cooperative Weichteilsarkom Gruppe September 2006

10. Ixabepilone in Treating Young Patients With Refractory Solid Tumors This study is currently recruiting patients. Verified by National Cancer Institute (NCI) June 2007

11. A Pilot Study of Tumor Cell Vaccine for High-Risk Solid Tumor Patients Following Stem Cell Transplantation This study is currently recruiting patients. Verified by University of Michigan Cancer Center November 2006

12. Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer This study is currently recruiting patients. Verified by National Cancer Institute (NCI) March 2007

13. Irinotecan in Treating Patients With Newly Diagnosed Ewing's Sarcoma This study is currently recruiting patients. Verified by National Cancer Institute (NCI) November 2006

14. Sorafenib in Treating Patients With Soft Tissue Sarcomas This study is currently recruiting patients. Verified by National Cancer Institute (NCI) November 2006

15. Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse This study is currently recruiting patients. Verified by Institut Gustave Roussy September 2006

16. Study of ZIO-201 in Advanced SarcomaThis study is currently recruiting patients. (Intravenous Isophosporamide Mustard). Verified by ZIOPHARM February 2007

17. Imatinib Mesylate in Patients With Refractory Desmoplastic Small Round Cell Tumors - This study is currently recruiting patients. Verified by Novartis January 2007

18. Ecteinascidin 743 in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors -A Phase II Study Of Trabectedin (ET-743, Yondelis®) in Children With Recurrent Rhabdomyosarcoma, Ewing Sarcoma, or Nonrhabdomyosarcomatous Soft Tissue Sarcoma. - This study is not yet open for patient recruitment. Verified by National Cancer Institute (NCI) February 2007

19. Cytarabine in Treating Young Patients With Recurrent or Refractory Ewing's Sarcoma - Phase II Trial of Intermediate-Dose Cytarabine to Modulate EWS/FLI for Children and Young Adults With Recurrent or Refractory Ewing Sarcoma - This study is currently recruiting patients. Verified by National Cancer Institute (NCI) June 2007Cytarabine

20. Trial of Dasatinib in Advanced Sarcomas - This study is not yet open for patient recruitment. Verified by Sarcoma Alliance for Research through Collaboration April 2007

21. Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas - This study is currently recruiting patients. Verified by National Cancer Institute (NCI) May 2007

Phase III Clinical Trials
1.Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma - Adults. This study is currently recruiting patients. Verified by National Cancer Institute (NCI) November 2006.

2. Study to Provide Access to Trabectedin in Patients With Soft Tissue Sarcoma Who Have Persistent or Recurrent Disease and Who Are Not Expected to Benefit From Currently Available Standard of Care - (Yondelis) 18 Years and above. This study is currently recruiting patients. Verified by Johnson & Johnson Pharmaceutical Research & Development, L.L.C. May 2007

Find Clinical Trials
There may be some duplications of the above information. You should be able to follow the link to this site and specifically check what clinical trials are offered at each research facility.

1. US National Institute of Health - A searchable database of past and current clinical trials available.

2. City of Hope Clinical Trials Online -A searchable database of all clinical trials available at this facility.

3. University of Florida Shands Cancer Center - A searchable database of all clinical trials available at this facility. Requires registration.

4. Center Watch: Oncology

5. Cancertrialshelp.org

6. Fred Hutchinson Cancer Research Center -Searchable database

7. MSKCC Soft Tissue Sarcoma Trials

8. CureSeach Clinical Trials -Searchable database for children and young people with cancer.

9. Liddy Shriver Initiative Clinical Trials - Updated regularly. Good source when looking specifically for sarcoma Clinical Trials. Includes trials for adults and children.

DSRCT References
Contact: dsrct.wiki@gmail.com

'Disclaimer: The information of this page is not intended to be an endorsement for any clinical trial, drug, or treatment method. Please check with your health care professional about whether these clinical trials are beneficial in your own situation.'