Metroid/The Simpsons

Cast

 * Mario (from Mario) as Homer
 * Samus as Marge
 * Shadow (from Sonic) as Bart
 * Zero Suit Samus as Lisa
 * Pikachu (from Pokemon) as Lenny
 * Sonic (from Sonic) as Ned Flanders
 * Knuckles (from Sonic) as Principal Skinner
 * and more