Clinical Trials

Introduction
This section will provide links to various Clinical Trials that may be of interest to patients with desmoplastic small round cell tumors. Please check the links, the dates of the trial, eligibility, and contact information thoroughly.

As with any treatment for DSRCT some of these drugs may work for certain patients depending upon body type, age, health circumstances, disease stage, and probably just luck.

Locations for the clinical trials may be varied or may be localized, please check with your physician or call directly. You may be able to find a clinical trial closer to where you live. Ask.

Clinical Trials may be conducted by government health agencies such as NIH, researchers affiliated with a hospital or university medical program, independent researchers, or private industry.

Please remember that in Clinical Trials, especially Phase 1 trials that you may not be receiving the best dosage of drug (you may even receive a placebo) to treat your disease. Clinical Trials should be undertaken at the advice and guidance of a qualified oncologist who is interested in your specific well being. The Trial may not be effective for your needs. Consider also that Clinical Trials will take up valuable time.

Phase 1 Clinical Trials - First study that determines how the drugs will affect human beings, the side effects associated with increasing doses, and to begin the process of evaluating the drugs effectiveness; may include healthy participants and/or patients. Phase 1 trials generally can include a large group of people. Phase 1 trials are investigational and patients should remember that they may be in a cohort that does not receive the full benefit of the drugs or treatments.
 * Important Definitions:

Phase II

Phase 1 Clinical Trials
1. 17-N-Allylamino-17-Demethoxygeldanamycin (17-AAG) in Treating Young Patients With Recurrent or Refractory Leukemia or Solid Tumors -This study is currently recruiting patients. April 2006

2. Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer -This study is currently recruiting patients. April 2006

Phase II Clinical Trials
1. Phase II Trial of Imatinib Mesylate (Gleevec) in Therapy of Ewing's Family of Tumors and Desmoplastic Small Round Cell Tumors

2. Phase II Study of AP23573, An MTOR Inhibitor, in Patients with Advanced Sarcoma - This trial may be conducted in other locations too, please check with your physician.

3. Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors -This study is currently recruiting patients. April 2006

4. Chemotherapy Followed by Donor Peripheral Stem Cell Transplantation in Treating Young Patients With Recurrent Sarcoma - January 2006. Recruiting.

5. Mitomycin as a Hyperthermic Peritoneal Perfusion in Treating Patients With Malignant Ascites - April 2006. Recruiting.

6. FR901228 (Depsipeptide)  in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma December 2005. Recruiting.

7. Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors October 2006

8. Ecteinascidin 743 in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors - [Yondelis] Not yet recruiting, October 2006

9. a Multicenter Clinical Trial for the Treatment of Children and Adolescents With Soft Tissue Sarcoma Stage 4 September 2006

Phase III Clinical Trials
1.Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma - Adults. Recruiting August 2006.

2. Study to Provide Access to Trabectedin in Patients With Soft Tissue Sarcoma Who Have Persistent or Recurrent Disease and Who Are Not Expected to Benefit From Currently Available Standard of Care - 18 Years and above. October 2006

Find Clinical Trials
There may be some duplications of the above information. You should be able to follow the link to this site and specifically check what clinical trials are offered at each research facility.

1. US National Institute of Health - A searchable database of past and current clinical trials available.

2. City of Hope Clinical Trials Online -A searchable database of all clinical trials available at this facility.

3. University of Florida Shands Cancer Center - A searchable database of all clinical trials available at this facility. Requires registration.

4. Center Watch: Oncology

5. Cancertrialshelp.org

6. Fred Hutchinson Cancer Research Center -Searchable database

7. MSKCC Soft Tissue Sarcoma Trials

8. CureSeach Clinical Trials -Searchable database for children and young people with cancer.

DSRCT References
Contact: dsrct.wiki@gmail.com

'Disclaimer: The information of this page is not intended to be an endorsement for any clinical trial, drug, or treatment method. Please check with your health care professional about whether these clinical trials are beneficial in your own situation.'