FLU PPI

Objectives: Identify from among proteomics data host factors that modulate influenza viral polymerase activity by functional genomics, map protein-protein interactions and mechanisms of modulation on the viral life cycle (validation of proteomics and functional genomics), and strain-specific differences. Adapt exBiFC assay for co-localization studies (PMID: 17191610). Contribute to DFIM, structural studies on M1 and NP (in collaboration), and vPOL epidemiological and functional modeling.