MedUpdates

WBC Markers:

White cell markers oversimplified:

* PAS+ chunks ("blocks"): immature lymphocytes or M6 leukemia

TdT: immature lymphocytes

E-rosettes: T-cells

{16282} E-rosette, around a T-cell

CD4, CD8, others: T-cells (various kinds)


 * CD68: common macrophages

CD1a (T6): some T-cells, all Langerhans macrophages (* works best on frozen sections)

CD10 (CALLA): most B-cells

CD45 ("common leukocyte antigen"): all white cells (* exception: Reed Sternberg cells)

Surface Ig(M, etc): B-cells

kappa, lambda: B-cell, plasma cells

cytoplasmic Ig: plasma cells

nonspecific esterase: monocytes

Fc receptor: B-cells, monocytes

TRAP: hairy-cell leukemia

HLA-D/DR /Ia: Langerhans cells and other antigen-presenting macrophages; some other cells

lysozyme: monocytes


 * alpha1-antichymotrypsin: monocytes

erythrophagocytosis: monocytes

(myelo-)peroxidase: granulocytes


 * Sudan black: granulocytes


 * chloroacetate esterase: neutrophils, basophils, mast cells

platelet markers: megakaryocytes


 * PAS+ diffusely: erythrocytes, megakaryocytes/platelets


 * S-100, CD1/T6: dendritic ("Langerhans") macrophages

more at http://www.pathguy.com/lectures/spleen.htm