The characters passed away along with them

The Big Bang Theory
The unseen character of Mrs. Wolowitz on The Big Bang Theory took a trip to Florida and passed away there in her sleep right after the actress who provided her voice, Carol Ann Susi, passed away from cancer complications. There are quite a few episodes dealing with the in-universe aftermath, including the characters holding a memorable toast for her and her son, Howard trying to get her ashes right after they were misplaced.