The Simpsons/PAC-MAN

Homer as Pac-Man

Marge as Ms. Pac-Man

Lenny as Morris

Maggie as Pac-Baby (I know Maggie is female)

Principal Skineer as Grump

Moe as Clyde

Mr. Burns as Mezmeron

Roter (from Sonic) as Pinky

Bart as Inky

Lisa as Sue

Ralph as Blinky

and more